CHEMPACIFIC 38183

Base Information

• Chemical Name: CHEMPACIFIC 38183
• CAS No.: 1620-72-0
• Molecular Formula: C7H6F3N
• Molecular Weight: 161.127
• Hs Code.: 2933399090
• Mol file: 1620-72-0.mol

Synonyms:6-methyl-2-(trifluoromethyl)pyridine;2-Methyl-6-trifluormethyl-pyridin;2-trifluoromethyl-6-methylpyridine;6-Trifluoromethyl-2-picoline;2-Methyl-6-trifluoromethyl-pyridine;

Chemical Property of CHEMPACIFIC 38183

Chemical Property:

• Vapor Pressure: 13.5mmHg at 25°C
• Melting Point: 12.5 °C
• Boiling Point: 127.4oC at 760 mmHg
• PKA: 1.27±0.12(Predicted)
• Flash Point: 30.9oC
• PSA: 12.89000
• Density: 1.216g/cm3
• LogP: 2.40880
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Methyl-6-(trifluoromethyl)pyridine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of CHEMPACIFIC 38183

There total 12 articles about CHEMPACIFIC 38183 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.48%

methylmagnesium chloride (676-58-4) + 2-chloro-6-trifluoromethylpyridine (39890-95-4) → 2-methyl-6-(trifluoromethyl)pyridine (1620-72-0)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; at 0 - 70 ℃; for 16h; Inert atmosphere;

Reference yield: 43.0%

2-bromo-6-methylpyridine (5315-25-3) + iodotrifluoromethane (2314-97-8,263005-66-9) → 2-methyl-6-(trifluoromethyl)pyridine (1620-72-0)

Guidance literature:

With N,N,N,N,N,N-hexamethylphosphoric triamide; copper; at 112 - 130 ℃; autoclave;

DOI:10.1248/cpb.38.2446

Reference yield: 9.0%

α-picoline (109-06-8) + Bromotrifluoromethane (75-63-8) → 2-methyl-6-(trifluoromethyl)pyridine (1620-72-0) + 4-methylbenzotrifluoride (6140-17-6) + 1-methyl-3-trifluoromethyl-benzene (401-79-6) + 2-methylbenzotrifluoride (13630-19-8)

Guidance literature:

With sodium metabisulfite; sulfur dioxide; zinc; In N,N-dimethyl-formamide; at 65 ℃; for 3h; under 5250.4 - 6000.5 Torr;

upstream raw materials:

Z-piperylene

trifluoroacetonitrile

α-picoline

Bromotrifluoromethane

Downstream raw materials:

6-(trifluoromethyl)pyridine-2-carboxylic acid

6-(trifluoromethyl)-2-pyridinecarboxaldehyde

[6-(trifluoromethyl)pyridin-2-yl]methanol

2,6-dimethyl-4-(6-trifluoromethyl-2-pyridyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-β-(N-benzyl-N-methylamino)ethyl ester 5-methyl ester

Refernces

• 1、 -. "NOVEL NEUROKININ 1 RECEPTOR ANTAGONIST COMPOUNDS II". Page/Page column 58. . Retrieved 2015/03/13.
• 2、 Mormino, Michael G.,Fier, Patrick S.,Hartwig, John F.. "Copper-mediated perfluoroalkylation of heteroaryl bromides with (phen)CuRF". . p. 1744 - 1747. Retrieved 2014/04/17.