2-AMino-6-chloropurine -9-beta-D-(2'-deoxy-2'-fluoro)-arabinoriboside

Base Information

Chemical Name:2-AMino-6-chloropurine -9-beta-D-(2'-deoxy-2'-fluoro)-arabinoriboside
CAS No.:144924-88-9
Molecular Formula:C10H11ClFN5O3
Molecular Weight:303.68
Hs Code.:
Mol file:144924-88-9.mol

Synonyms:2-AMino-6-chloropurine -9-beta-D-(2'-deoxy-2'-fluoro)-arabinoriboside;2-AMino-6-chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purine;6-Chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-9H-purin-2-amine

Suppliers and Price of 2-AMino-6-chloropurine -9-beta-D-(2'-deoxy-2'-fluoro)-arabinoriboside

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
(2R,3R,4S,5R)-5-(2-Amino-6-chloro-9H-purin-9-yl)-4-fluoro-2-(hydroxymethyl)tetrahydrofuran-3-ol 97%
100mg
$ 1780.00

Chemenu
(2R,3R,4S,5R)-5-(2-amino-6-chloro-9H-purin-9-yl)-4-fluoro-2-(hydroxymethyl)tetrahydrofuran-3-ol 97%
100mg
$ 1664.00

Alichem
(2R,3R,4S,5R)-5-(2-Amino-6-chloro-9H-purin-9-yl)-4-fluoro-2-(hydroxymethyl)tetrahydrofuran-3-ol
100mg
$ 1886.80

Total 7 raw suppliers

Chemical Property of 2-AMino-6-chloropurine -9-beta-D-(2'-deoxy-2'-fluoro)-arabinoriboside

Chemical Property:

PSA：119.31000
LogP:0.23180

Purity/Quality:

97% ^*data from raw suppliers

(2R,3R,4S,5R)-5-(2-Amino-6-chloro-9H-purin-9-yl)-4-fluoro-2-(hydroxymethyl)tetrahydrofuran-3-ol 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-AMino-6-chloropurine -9-beta-D-(2'-deoxy-2'-fluoro)-arabinoriboside

There total 7 articles about 2-AMino-6-chloropurine -9-beta-D-(2'-deoxy-2'-fluoro)-arabinoriboside which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 118373-61-8
2-amino-6-chloro-9-(3',5'-di-O-benzoyl-2'-deoxy-2'-fluoro-β-D-arabinofuranosyl)-9H-purine

: 144924-88-9
9-(2'-deoxy-2'-fluoro-β-D-arabinofuranos-1'-yl)-2-amino-6-chloropurine

Guidance literature:: With ammonia; In methanol; for 4h;
DOI:10.1080/15257779408013236

Reference yield:

: 10310-21-1
2-Amino-6-chloropurin

: 850883-62-4
2-deoxy-2-fluoro-α-D-arabinofuranose 1-phosphate

: 144924-88-9
9-(2'-deoxy-2'-fluoro-β-D-arabinofuranos-1'-yl)-2-amino-6-chloropurine

Guidance literature:: purine nucleoside phosphorylase; In water; at 50 ℃; for 336h; pH=7.5; Aqueous phosphate buffer; Enzymatic reaction;

Reference yield:

: 97614-43-2
1,3,5-tri-O-benzoyl-2-deoxy-2-fluoro-α-D-arabinofuranose

: 144924-88-9
9-(2'-deoxy-2'-fluoro-β-D-arabinofuranos-1'-yl)-2-amino-6-chloropurine

Guidance literature:: Multi-step reaction with 3 steps

1: 99 percent / HBr, AcOH / CH₂Cl₂ / 20 h / Ambient temperature

2: 1.) bis(trimethylsilyl)acetamide, 2.) Hg(CN)2 / 1.) CH₃CN, room temperature, 30 min, 2.) C₆H₆, reflux, 3 h

3: 75 percent / NH₃ / methanol / 4 h

With ammonia; hydrogen bromide; mercury(II) cyanide; acetic acid; bis-(trimethylsilyl)acetamide; In methanol; dichloromethane;
DOI:10.1080/15257779408013236