Di-tert-butyl maleate

Base Information

Chemical Name:Di-tert-butyl maleate
CAS No.:18305-60-7
Molecular Formula:C12H20O4
Molecular Weight:228.288
Hs Code.:2917190090
NSC Number:134487
DSSTox Substance ID:DTXSID50880692
Nikkaji Number:J274.499F
Wikidata:Q82862048
Mol file:18305-60-7.mol

Synonyms:Di-tert-butyl maleate;18305-60-7;ditert-butyl (Z)-but-2-enedioate;Maleic acid, di-t-butyl ester;MFCD23381095;Di-tert-butylmaleate;NSC134487;SCHEMBL375029;di-(2-methyl-2-propyl) maleate;DTXSID50880692;MSVGHYYKWDQHFV-FPLPWBNLSA-N;AKOS016010621;CS-W003918;DS-2824;NSC-134487;Di(tert-butyl) (2Z)-2-butenedioate #;1,4-di-tert-butyl (2Z)-but-2-enedioate;2-Butenedioic acid (2Z)-, bis(1,1-dimethylethyl) ester

Suppliers and Price of Di-tert-butyl maleate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Di-tert-butylMaleate
250mg
$ 80.00

Matrix Scientific
Di-tert-butylmaleate >95%
1g
$ 684.00

Crysdot
Di-tert-butylmaleate 95%
5g
$ 594.00

Crysdot
Di-tert-butylmaleate 95%
10g
$ 950.00

Biosynth Carbosynth
Di-tert-butyl maleate
250 mg
$ 110.00

Biosynth Carbosynth
Di-tert-butyl maleate
100 mg
$ 55.00

Biosynth Carbosynth
Di-tert-butyl maleate
1 g
$ 331.25

Biosynth Carbosynth
Di-tert-butyl maleate
500 mg
$ 190.00

Biosynth Carbosynth
Di-tert-butyl maleate
2 g
$ 563.00

American Custom Chemicals Corporation
DI-TERT-BUTYL MALEATE 95.00%
5MG
$ 505.23

Total 17 raw suppliers

Chemical Property of Di-tert-butyl maleate

Chemical Property:

Melting Point:64-65 °C
Boiling Point:273.2±13.0 °C(Predicted)
PSA：52.60000
Density:1.004±0.06 g/cm3(Predicted)
LogP:2.22600
Storage Temp.:2-8°C
XLogP3:2.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:228.13615911
Heavy Atom Count:16
Complexity:259

Purity/Quality:

97% ^*data from raw suppliers

Di-tert-butylMaleate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)C=CC(=O)OC(C)(C)C
Isomeric SMILES:CC(C)(C)OC(=O)/C=C\C(=O)OC(C)(C)C
Uses Di-tert-butyl Maleate is used as a reactant in the synthesis of J-104,118, a novel, potent inhibitor of squalene synthase.

Technology Process of Di-tert-butyl maleate

There total 21 articles about Di-tert-butyl maleate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 35059-50-8
t-butyl diazoacetate

: 18305-60-7
di-tert-butyl maleate

Guidance literature:: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In dichloromethane; at 20 ℃;
DOI:10.1002/chem.200601692

Reference yield: 75.0%

: 110-16-7,26099-09-2
maleic acid

: 115-11-7,15220-85-6
isobutene

: 18305-60-7
di-tert-butyl maleate

Guidance literature:: With sulfuric acid; In di-isopropyl ether; toluene; at 40 ℃; for 4h; under 760.051 Torr; Temperature; Solvent;

Reference yield: 73.0%

: 108-31-6
maleic anhydride

: 115-11-7,15220-85-6
isobutene

: 18305-60-7
di-tert-butyl maleate

Guidance literature:: maleic anhydride; With toluene-4-sulfonic acid; In di-isopropyl ether; water; toluene; at 30 ℃; for 2h;

isobutene; In di-isopropyl ether; water; toluene; at 30 ℃; for 4h; under 760.051 Torr; Reagent/catalyst; Solvent;