2,7-BIS-(1-TERT-BUTOXYCARBONYLPYRROL-2-YL)ETHYNYL-1,8-NAPHTHRIDINE

Base Information

Chemical Name:2,7-BIS-(1-TERT-BUTOXYCARBONYLPYRROL-2-YL)ETHYNYL-1,8-NAPHTHRIDINE
CAS No.:467435-77-4
Molecular Formula:C₃₀H₂₈N₄O₄
Molecular Weight:508.577
Hs Code.:
Mol file:467435-77-4.mol

Synonyms:2,7-BIS-(1-TERT-BUTOXYCARBONYLPYRROL-2-YL)ETHYNYL-1,8-NAPHTHRIDINE;2,2'-(1,8-Naphthyridine-2,7-diyldi-2,1-ethynediyl)bis-1H-pyrrole-1-carboxylic Acid Bis(1,1-diMethylethyl) Ester

Suppliers and Price of 2,7-BIS-(1-TERT-BUTOXYCARBONYLPYRROL-2-YL)ETHYNYL-1,8-NAPHTHRIDINE

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2,7-Bis-(1-tert-butoxycarbonylpyrrol-2-yl)ethynyl-1,8-naphthridine
10mg
$ 165.00

TRC
2,7-Bis-(1-tert-butoxycarbonylpyrrol-2-yl)ethynyl-1,8-naphthridine
100mg
$ 1320.00

Medical Isotopes, Inc.
2,7-Bis-(1-tert-butoxycarbonylpyrrol-2-yl)ethynyl-1,8-naphthridine
10 mg
$ 875.00

American Custom Chemicals Corporation
2,7-BIS-(1-TERT-BUTOXYCARBONYLPYRROL-2-YL)ETHYNYL-1,8-NAPHTHRIDINE 95.00%
10MG
$ 329.70

Total 1 raw suppliers

Chemical Property of 2,7-BIS-(1-TERT-BUTOXYCARBONYLPYRROL-2-YL)ETHYNYL-1,8-NAPHTHRIDINE

Chemical Property:

PSA：88.24000
LogP:5.59880
Solubility.:Acetone, DMF, DMSO, Ethyl Acetate, Methanol

Purity/Quality:: 2,7-Bis-(1-tert-butoxycarbonylpyrrol-2-yl)ethynyl-1,8-naphthridine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2,7-BIS-(1-TERT-BUTOXYCARBONYLPYRROL-2-YL)ETHYNYL-1,8-NAPHTHRIDINE

There total 3 articles about 2,7-BIS-(1-TERT-BUTOXYCARBONYLPYRROL-2-YL)ETHYNYL-1,8-NAPHTHRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 55243-02-2
2,7-dichloro-1,8-naphthyridine

: 467435-75-2
2-ethynylpyrrole-1-carboxylic acid tert-butyl ester

: 467435-77-4
2,7-bis-(1-tert-butoxycarbonylpyrrol-2-yl)ethynyl-1,8-naphthyridine

Guidance literature:: With copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; at 20 ℃; for 40h;
DOI:10.1021/ja039237w

Reference yield:

: 117657-37-1
2-bromo-pyrrole-1-carboxylic acid tert-butyl ester

: 467435-77-4
2,7-bis-(1-tert-butoxycarbonylpyrrol-2-yl)ethynyl-1,8-naphthyridine

Guidance literature:: Multi-step reaction with 3 steps

1: 79 percent / triethylamine; CuI / Pd(PPh₃)2Cl₂ / dioxane / 0.33 h / 80 °C

2: 84 percent / KF; MeOH / 6 h / 20 °C

3: 78 percent / triethylamine; CuI / Pd(PPh₃)2Cl₂ / tetrahydrofuran / 40 h / 20 °C

With methanol; potassium fluoride; copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1,4-dioxane; 1: Sonogashira coupling / 3: Sonogashira coupling;
DOI:10.1021/ja039237w

Reference yield:

: 467435-72-9
2-(trimethylsilylethynyl)pyrrole-1-carboxylic acid tert-butyl ester

: 467435-77-4
2,7-bis-(1-tert-butoxycarbonylpyrrol-2-yl)ethynyl-1,8-naphthyridine

Guidance literature:: Multi-step reaction with 2 steps

1: 84 percent / KF; MeOH / 6 h / 20 °C

2: 78 percent / triethylamine; CuI / Pd(PPh₃)2Cl₂ / tetrahydrofuran / 40 h / 20 °C

With methanol; potassium fluoride; copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 2: Sonogashira coupling;
DOI:10.1021/ja039237w