7-bromo-5-fluoro-1H-indole-2-carboxylic acid ethyl ester

Base Information

• Chemical Name: 7-bromo-5-fluoro-1H-indole-2-carboxylic acid ethyl ester
• CAS No.: 396076-60-1
• Molecular Formula: C11H9BrFNO2
• Molecular Weight: 286.1
• Mol file: 396076-60-1.mol

Synonyms:7-bromo-5-fluoro-1H-indole-2-carboxylic acid ethyl ester;ethyl 7-bromo-5-fluoro-1H-indole-2-carboxylate

Chemical Property of 7-bromo-5-fluoro-1H-indole-2-carboxylic acid ethyl ester

Chemical Property:

• PSA: 42.09000
• LogP: 3.24620
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99%, ^*data from raw suppliers

Ethyl7-bromo-5-fluoro-1H-indole-2-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-bromo-5-fluoro-1H-indole-2-carboxylic acid ethyl ester

There total 4 articles about 7-bromo-5-fluoro-1H-indole-2-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

(E)-ethyl 2-(2-(2-bromo-4-fluorophenyl)hydrazono)propanoate (1412398-37-8) → ethyl 7-bromo-5-fluoro-1H-indole-2-carboxylate (396076-60-1)

Guidance literature:

With toluene-4-sulfonic acid; In toluene; for 1.5h; Heating / reflux;

Reference yield: 68.0%

2-oxo-propionic acid ethyl ester (617-35-6) + sodium hydrogencarbonate (144-55-8) + (2-bromo-4-fluorophenyl)hydrazine (299440-21-4) → ethyl 7-bromo-5-fluoro-1H-indole-2-carboxylate (396076-60-1)

Guidance literature:

In diethyl ether; ethanol; hexane; toluene;

Reference yield:

2-bromo-4-fluoroaniline (1003-98-1) → ethyl 7-bromo-5-fluoro-1H-indole-2-carboxylate (396076-60-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: hydrogenchloride; sodium nitrite / water / 1 h / -5 °C

1.2: 2 h / -5 °C

2.1: toluene-4-sulfonic acid / toluene / 2 h / Reflux

3.1: toluene-4-sulfonic acid / toluene / 16 h / 110 °C / Dean-Stark

With hydrogenchloride; toluene-4-sulfonic acid; sodium nitrite; In water; toluene;

upstream raw materials:

2-oxo-propionic acid ethyl ester

sodium hydrogencarbonate

(2-bromo-4-fluorophenyl)hydrazine

(E)-ethyl 2-(2-(2-bromo-4-fluorophenyl)hydrazono)propanoate

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