N-AcetylneuraMinic acid Methyl ester

Base Information

• Chemical Name: N-AcetylneuraMinic acid Methyl ester
• CAS No.: 32766-94-2
• Molecular Formula: C12H21NO9
• Molecular Weight: 323.29644
• Mol file: 32766-94-2.mol

Synonyms:N-Acetyl-neuraminsaeure-methylester;(4S,5R,6R,7S,8R)-5-Acetylamino-4,6,7,8,9-pentahydroxy-2-oxo-nonanoic acid methyl ester;

Chemical Property of N-AcetylneuraMinic acid Methyl ester

Chemical Property:

• Boiling Point: 719.6±60.0 °C(Predicted)
• PKA: 13.03±0.20(Predicted)
• PSA: 173.62000
• Density: 1.452±0.06 g/cm3(Predicted)
• LogP: -3.54990

Purity/Quality:

NLT 98% ^*data from raw suppliers

N-Acetylneuraminic Acid Methyl Ester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-AcetylneuraMinic acid Methyl ester

There total 2 articles about N-AcetylneuraMinic acid Methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methanol (67-56-1) + N-Acetylneuraminic acid (131-48-6,14752-56-8,5977-25-3,6225-16-7,6918-20-3) → N-acetyl-neuraminic acid methyl ester (32766-94-2)

Guidance literature:

With Amberlite IR 120 H⁽¹⁺⁾ form; at 20 ℃; for 15h;

DOI:10.1016/j.tet.2007.05.049

Reference yield:

→ N-Acetylneuraminsaeure-methylester (6931-67-5,32766-94-2)

Guidance literature:

N-Acetylneuraminsaeure, Diazomethan;

DOI:10.1111/j.1432-1033.1971.tb01588.x

Reference yield:

N-acetyl-neuraminic acid methyl ester (32766-94-2) + O-benzylhydoxylamine hydrochloride (2687-43-6) → (4S,5R,6R,7S,8R)-5-Acetylamino-2-[(Z)-benzyloxyimino]-4,6,7,8,9-pentahydroxy-nonanoic acid methyl ester

Guidance literature:

With 1-methyl-2-N,N-dimethylaminoethanol; In pyridine; methanol; at 50 ℃; for 0.166667h;

DOI:10.1016/S0008-6215(00)82581-1

upstream raw materials:

methanol

N-Acetylneuraminic acid

Downstream raw materials:

N-acetyl-4,7,8,9-tetra-O-acetyl-2-chloro-2-deoxyneuraminic acid methyl ester

Refernces

• 1、 Sato, Kazuki,Ikeda, Kiyoshi,Suzuki, Takashi,Aoyama, Shinya,Maki, Naoyoshi,Suzuki, Yasuo,Sato, Masayuki. "Synthesis of 4-O-[3-(aryl)prop-2-ynyl]-Neu5Ac2en and its 4-epi-analogs modified at C-4 by Sonogashira coupling reaction". . p. 7571 - 7581. Retrieved 2008/02/08.