(R)-6,6'-DIMETHYL-1,1'-BI-2-NAPHTHOL

Base Information

• Chemical Name: (R)-6,6'-DIMETHYL-1,1'-BI-2-NAPHTHOL
• CAS No.: 172877-00-8
• Molecular Formula: C₂₂H₁₈O₂
• Molecular Weight: 314.384
• Mol file: 172877-00-8.mol

Synonyms:(R)-6,6'-DIMETHYL-1,1'-BI-2-NAPHTHOL;(S)-6,6'-DIMETHYL-1,1'-BI-2-NAPHTHOL

Chemical Property of (R)-6,6'-DIMETHYL-1,1'-BI-2-NAPHTHOL

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-6,6'-DIMETHYL-1,1'-BI-2-NAPHTHOL

There total 5 articles about (R)-6,6'-DIMETHYL-1,1'-BI-2-NAPHTHOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

(S)-6,6'-dibromo-1,1'-binaphthalene-2,2'-diol (79082-80-7) + methyl iodide (74-88-4) → 1,1'-bi-(6-methyl-2-naphthol) (172170-94-4,172876-99-2,172877-00-8)

Guidance literature:

(S)-6,6'-dibromo-1,1'-binaphthalene-2,2'-diol; With n-butyllithium; In tetrahydrofuran; hexane; at -78 - -70 ℃; for 5h; Inert atmosphere;

methyl iodide; In tetrahydrofuran; hexane; at -50 ℃; for 0.75h; Inert atmosphere;

With hydrogenchloride; In tetrahydrofuran; hexane; water; at 20 ℃; pH=< 1; Cooling with ice;

DOI:10.1021/jo1025892

Reference yield: 79.0%

2-methyl-6-hydroxynaphthalene (17579-79-2) + 2-hydroxy-6-methyl-naphthalene-1-diazonium-betaine → 1,1'-bi-(6-methyl-2-naphthol) (172170-94-4,172876-99-2,172877-00-8)

Guidance literature:

With palladium diacetate; In dichloromethane; at 20 ℃; for 36h; enantioselective reaction; Inert atmosphere; Schlenk technique;

DOI:10.1007/s11426-021-1003-9

Reference yield:

2-methyl-6-hydroxynaphthalene (17579-79-2) → 1,1'-bi-(6-methyl-2-naphthol) (172170-94-4,172876-99-2,172877-00-8)

Guidance literature:

With hydrogenchloride; iron(III) chloride;

DOI:10.1080/00222890109601914

upstream raw materials:

2-methyl-6-hydroxynaphthalene

hydrogenchloride

iron(III) chloride

(S)-6,6'-dibromo-1,1'-binaphthalene-2,2'-diol