6-BroMo-1-[(1S)-1-[[[(1,1-diMethylethyl)diMethylsilyl]oxy]Methyl]-2-Methylpropyl]-7-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid Ethyl Ester

Base Information

Chemical Name:6-BroMo-1-[(1S)-1-[[[(1,1-diMethylethyl)diMethylsilyl]oxy]Methyl]-2-Methylpropyl]-7-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid Ethyl Ester
CAS No.:934161-52-1
Molecular Formula:C₂₃H₃₃BrFNO₄Si
Molecular Weight:514.507
Hs Code.:
Mol file:934161-52-1.mol

6-BroMo-1-[(1S)-1-[[[(1,1-diMethylethyl)diMethylsilyl]oxy]Methyl]-2-Methylpropyl]-7-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid Ethyl Ester

Synonyms:6-BroMo-1-[(1S)-1-[[[(1,1-diMethylethyl)diMethylsilyl]oxy]Methyl]-2-Methylpropyl]-7-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid Ethyl Ester;6-bromo-1-((S)-1-tert-butyldimethylsilyloxymethyl-2-methylpropyl)-7-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester

Suppliers and Price of 6-BroMo-1-[(1S)-1-[[[(1,1-diMethylethyl)diMethylsilyl]oxy]Methyl]-2-Methylpropyl]-7-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid Ethyl Ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
6-Bromo-1-[(1S)-1-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-2-methylpropyl]-7-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylicAcidEthylEster
5mg
$ 90.00

Medical Isotopes, Inc.
6-Bromo-1-[(1S)-1-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-2-methylpropyl]-7-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylicAcidEthylEster
100 mg
$ 2120.00

Biosynth Carbosynth
6-Bromo-1-[(1S)-1-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-2-methylpropyl]-7-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid ethyl ester
50 mg
$ 841.50

Biosynth Carbosynth
6-Bromo-1-[(1S)-1-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-2-methylpropyl]-7-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid ethyl ester
25 mg
$ 463.00

Biosynth Carbosynth
6-Bromo-1-[(1S)-1-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-2-methylpropyl]-7-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid ethyl ester
10 mg
$ 254.50

Biosynth Carbosynth
6-Bromo-1-[(1S)-1-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-2-methylpropyl]-7-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid ethyl ester
5 mg
$ 140.00

Biosynth Carbosynth
6-Bromo-1-[(1S)-1-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-2-methylpropyl]-7-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid ethyl ester
100 mg
$ 1529.00

AK Scientific
Ethyl6-bromo-1-[(2S)-1-[tert-butyl(dimethyl)silyl]oxy-3-methylbutan-2-yl]-7-fluoro-4-oxoquinoline-3-carboxylate
100mg
$ 2114.00

A1 Biochem Labs
(S)-ethyl6-bromo-1-(1-((tert-butyldimethylsilyl)oxy)-3-methylbutan-2-yl)-7-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate 95%
5 g
$ 1400.00

Total 2 raw suppliers

Chemical Property of 6-BroMo-1-[(1S)-1-[[[(1,1-diMethylethyl)diMethylsilyl]oxy]Methyl]-2-Methylpropyl]-7-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid Ethyl Ester

Chemical Property:

PSA：57.53000
LogP:6.29870
Solubility.:Dichloromethane, Ethyl Acetate, Methanol

Purity/Quality:

99% ^*data from raw suppliers

6-Bromo-1-[(1S)-1-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-2-methylpropyl]-7-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylicAcidEthylEster ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses 6-BroMo-1-[(1S)-1-[[[(1,1-diMethylethyl)diMethylsilyl]oxy]Methyl]-2-Methylpropyl]-7-fluoro-1 is used in the preparation of anti-HIV compounds.

Technology Process of 6-BroMo-1-[(1S)-1-[[[(1,1-diMethylethyl)diMethylsilyl]oxy]Methyl]-2-Methylpropyl]-7-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid Ethyl Ester

There total 4 articles about 6-BroMo-1-[(1S)-1-[[[(1,1-diMethylethyl)diMethylsilyl]oxy]Methyl]-2-Methylpropyl]-7-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid Ethyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 934161-50-9
6-bromo-7-fluoro-1-((S)-1-hydroxymethyl-2-methylpropyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester

: 18162-48-6
tert-butyldimethylsilyl chloride

: 934161-52-1
6-bromo-1-((S)-1-tert-butyldimethylsilyloxymethyl-2-methylpropyl)-7-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester

Guidance literature:: With 1H-imidazole; In toluene; at 50 ℃; for 3h;

Reference yield:

: 412319-88-1
ethyl-3,3-dimethylaminoacrylate

: 934161-52-1
6-bromo-1-((S)-1-tert-butyldimethylsilyloxymethyl-2-methylpropyl)-7-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: thionyl chloride / N,N-dimethyl-formamide / toluene / 6 h / 70 °C

1.2: 21 h / 70 °C

1.3: 1.5 h / 20 °C

2.1: 1,8-diazabicyclo-[5,4,0]-undecane / DMF (N,N-dimethyl-formamide) / 23 h / 20 °C

3.1: 1H-imidazole / toluene / 3 h / 50 °C

With 1H-imidazole; thionyl chloride; 1,8-diazabicyclo-[5,4,0]-undecane; N,N-dimethyl-formamide; In DMF (N,N-dimethyl-formamide); toluene;

Reference yield:

: 28314-83-2
5-bromo-2,4-difluoro-benzoic acid

: 934161-52-1
6-bromo-1-((S)-1-tert-butyldimethylsilyloxymethyl-2-methylpropyl)-7-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: thionyl chloride / N,N-dimethyl-formamide / toluene / 6 h / 70 °C

1.2: 21 h / 70 °C

1.3: 1.5 h / 20 °C

2.1: 1,8-diazabicyclo-[5,4,0]-undecane / DMF (N,N-dimethyl-formamide) / 23 h / 20 °C

3.1: 1H-imidazole / toluene / 3 h / 50 °C

With 1H-imidazole; thionyl chloride; 1,8-diazabicyclo-[5,4,0]-undecane; N,N-dimethyl-formamide; In DMF (N,N-dimethyl-formamide); toluene;