4-Fluorobenzoic acid phenacyl ester

Base Information

• Chemical Name: 4-Fluorobenzoic acid phenacyl ester
• CAS No.: 55153-22-5
• Molecular Formula: C₁₅H₁₁FO₃
• Molecular Weight: 258.249
• Hs Code.: 2916399090
• Mol file: 55153-22-5.mol

Synonyms:4-Fluorobenzoic acid phenacyl ester

Chemical Property of 4-Fluorobenzoic acid phenacyl ester

Chemical Property:

• PSA: 43.37000
• LogP: 2.86540

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Fluorobenzoic acid phenacyl ester

There total 2 articles about 4-Fluorobenzoic acid phenacyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

p-fluorotoluene (352-32-9) + acetophenone (98-86-2) → Phenacyl-p-fluorbenzoat (55153-22-5)

Guidance literature:

With tert.-butylhydroperoxide; iodine; sodium carbonate; In water; at 80 ℃; for 24h;

DOI:10.1039/c7ra02298k

Reference yield:

4-Fluorobenzoic acid (456-22-4) + α-bromoacetophenone (70-11-1) → Phenacyl-p-fluorbenzoat (55153-22-5)

Guidance literature:

With triethylamine; In acetone; at 30 ℃; Rate constant; Kinetics; Thermodynamic data;

DOI:10.1016/S0040-4020(01)90893-2

upstream raw materials:

4-Fluorobenzoic acid

α-bromoacetophenone

p-fluorotoluene

acetophenone

Refernces

• 1、 Pillay, M. Krishna,Kannan, K.,Ramasubramanian, P.. "KINETICS OF REACTION OF TRIETHYLAMMONIUM CARBOXYLATES WITH α-HALOGENOCARBONYL COMPOUNDS IN ORGANIC SOLVENTS. REACTION OF BENZOATES AND PHENOXYACETATES WITH PHENACYL BROMIDE IN ACETONE". . p. 3899 - 3908. Retrieved 2007/10/02.