N3-PEG8-CH2CH2COOH

Base Information

Chemical Name:N3-PEG8-CH2CH2COOH
CAS No.:1214319-92-2
Molecular Formula:C19H37N3O10
Molecular Weight:467.51118
Hs Code.:2929900090
Mol file:1214319-92-2.mol

Synonyms:N3-PEG8-CH2CH2COOH

Suppliers and Price of N3-PEG8-CH2CH2COOH

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

purepeg
N3-PEG8-CH2CH2COOH min.95%
250 mg
$ 229.00

purepeg
N3-PEG8-CH2CH2COOH min.95%
1 g
$ 575.00

Iris Biotech GmbH
N3-PEG?(8)-COOH
100 mg
$ 472.50

dPEG
Azido-dPEG??-acid
1000 mg
$ 575.00

dPEG
Azido-dPEG??-acid
100 mg
$ 225.00

dPEG
Azido-dPEG???-acid
100 mg
$ 250.00

ChemScene
Azido-PEG8-acid
100mg
$ 351.00

ChemScene
Azido-PEG8-acid
250mg
$ 585.00

BroadPharm
Azido-PEG8-acid 98%
1 G
$ 700.00

BroadPharm
Azido-PEG8-acid 98%
500 MG
$ 400.00

Total 19 raw suppliers

Chemical Property of N3-PEG8-CH2CH2COOH

Chemical Property:

PSA：160.89000
LogP:0.35696
Storage Temp.:-20°C
Solubility.:Soluble in Water, DMSO, DCM, DMF

Purity/Quality:

98%,99%, ^*data from raw suppliers

N3-PEG8-CH2CH2COOH min.95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Description Azido-PEG8-acid is a aqueous soluble PEG linker containing an azide (N3) and a terminal carboxylic acid (CO2H) group. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Technology Process of N3-PEG8-CH2CH2COOH

There total 13 articles about N3-PEG8-CH2CH2COOH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.22%

: 1623791-99-0
C₂₃H₄₅N₃O₁₀

: 1214319-92-2
27-azido-4,7,10,13,16,19,22,25-octaoxaheptacosanoic acid

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 25 ℃;

Reference yield: 50.0%

: 27-azido-4,7,10,13,16,19,22,25-octaoxa-1-((triisopropylsilyl)oxy)heptacosane

: 1214319-92-2
27-azido-4,7,10,13,16,19,22,25-octaoxaheptacosanoic acid

Guidance literature:: With Jones reagent; In acetone; at 20 ℃; for 0.75h; Inert atmosphere;
DOI:10.1016/j.ejmech.2020.112574

Reference yield:

: 112-60-7
Tetraethylene glycol

: 1214319-92-2
27-azido-4,7,10,13,16,19,22,25-octaoxaheptacosanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine; dmap / dichloromethane / 0 - 20 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 °C / Inert atmosphere

2.2: 3 h / 20 °C / Inert atmosphere

2.3: 2 h / 20 °C / Inert atmosphere

3.1: sodium hydride / tetrahydrofuran; mineral oil / 2 h / 0 °C / Inert atmosphere

3.2: 48 h / 20 °C / Inert atmosphere

4.1: Jones reagent / acetone / 0.75 h / 20 °C / Inert atmosphere

With dmap; Jones reagent; sodium hydride; triethylamine; In tetrahydrofuran; dichloromethane; acetone; mineral oil;
DOI:10.1016/j.ejmech.2020.112574