alpha-amine-omega-propionic acid octaethylene glycol

Base Information

• Chemical Name: alpha-amine-omega-propionic acid octaethylene glycol
• CAS No.: 756526-04-2
• Molecular Formula: C19H39NO10
• Molecular Weight: 441.519
• Hs Code.: 2942000090
• Mol file: 756526-04-2.mol

Synonyms:alpha-aMine-oMega-propionic acid octaethylene glycol;H2N-PEG8-CH2CH2COOH;α-AMine-ω-propionic acid octaethylene glycol;27-Amino-4,7,10,13,16,19,22,25-octaoxaheptacosanoic acid

Chemical Property of alpha-amine-omega-propionic acid octaethylene glycol

Chemical Property:

• Boiling Point: 547.1±50.0 °C(Predicted)
• PKA: 4.28±0.10(Predicted)
• PSA: 137.16000
• Density: 1.128±0.06 g/cm3(Predicted)
• LogP: 0.25290
• Storage Temp.: -20°C
• Solubility.: Soluble in Water, DMSO, DCM, DMF

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-Amino-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-oicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: Amino-PEG8-acid is a water soluble PEG linker consisting of an amino group (NH2) with a terminal carboxylic acid. The amine group is reactive with activated NHS esters, carbonyls (ketone, aldehyde) etc.

Technology Process of alpha-amine-omega-propionic acid octaethylene glycol

There total 14 articles about alpha-amine-omega-propionic acid octaethylene glycol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

27-azido-4,7,10,13,16,19,22,25-octaoxaheptacosanoic acid (1214319-92-2) → 1-amino-3,6,9.12,15,18,21,24-octaoxaheptacosan-27-oic acid (756526-04-2)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol; at 20 ℃; for 16h; under 750.075 Torr;

DOI:10.1016/j.ejmech.2020.112574

Reference yield:

tert-Butyl 1-amino-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-oate (756526-06-4) → 1-amino-3,6,9.12,15,18,21,24-octaoxaheptacosan-27-oic acid (756526-04-2)

Guidance literature:

With hydrogenchloride; In water; at 60 ℃; for 8h;

Reference yield:

Tetraethylene glycol (112-60-7) → 1-amino-3,6,9.12,15,18,21,24-octaoxaheptacosan-27-oic acid (756526-04-2)

Guidance literature:

Multi-step reaction with 5 steps

1.1: triethylamine; dmap / dichloromethane / 0 - 20 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 °C / Inert atmosphere

2.2: 3 h / 20 °C / Inert atmosphere

2.3: 2 h / 20 °C / Inert atmosphere

3.1: sodium hydride / tetrahydrofuran; mineral oil / 2 h / 0 °C / Inert atmosphere

3.2: 48 h / 20 °C / Inert atmosphere

4.1: Jones reagent / acetone / 0.75 h / 20 °C / Inert atmosphere

5.1: palladium 10% on activated carbon; hydrogen / ethanol / 16 h / 20 °C / 750.08 Torr

With dmap; Jones reagent; palladium 10% on activated carbon; hydrogen; sodium hydride; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; acetone; mineral oil;

DOI:10.1016/j.ejmech.2020.112574

upstream raw materials:

tert-butyl 1-hydroxy-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-oate

C₃₀H₅₂O₁₃S

tert-Butyl 1-amino-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-oate

octaethylene glycol

Downstream raw materials:

C₃₄H₅₄N₂O₁₄

Refernces

• 1、 -. "A-amido glycol propionic acid preparation method (by machine translation)". . . Retrieved 2017/10/22.