1-Benzyl-5-methyl-1H-benzimidazol-2(3H)-one

Base Information

• Chemical Name: 1-Benzyl-5-methyl-1H-benzimidazol-2(3H)-one
• CAS No.: 28643-35-8
• Molecular Formula: C15H14N2O
• Molecular Weight: 238.289
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID60443454
• Nikkaji Number: J99.744G
• Wikidata: Q82261288
• Mol file: 28643-35-8.mol

Synonyms:28643-35-8;AGN-PC-0N8QS9;DTXSID60443454;2-Benzimidazolinone, 1-benzyl-5-methyl-;1-Benzyl-5-methyl-1H-benzimidazol-2(3H)-one

Chemical Property of 1-Benzyl-5-methyl-1H-benzimidazol-2(3H)-one

Chemical Property:

• PSA: 38.05000
• LogP: 3.09860
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 238.110613074
• Heavy Atom Count: 18
• Complexity: 312

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC2=C(C=C1)N(C(=O)N2)CC3=CC=CC=C3

Technology Process of 1-Benzyl-5-methyl-1H-benzimidazol-2(3H)-one

There total 12 articles about 1-Benzyl-5-methyl-1H-benzimidazol-2(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1-benzyl-1-(2-chloro-4-methyl-phenyl)urea (906532-80-7) → 1-benzyl-5-methyl-1,3-dihydro-2H-benzo[d]imidazol-2-one (28643-35-8)

Guidance literature:

With water; sodium hydrogencarbonate; palladium diacetate; XPhos; In isopropyl alcohol; at 83 ℃; for 24h;

DOI:10.1021/ol061233j

Reference yield: 80.0%

1-benzyl-1-(2-bromo-4-methylphenyl)urea (1048344-44-0) → 1-benzyl-5-methyl-1,3-dihydro-2H-benzo[d]imidazol-2-one (28643-35-8)

Guidance literature:

With copper(l) iodide; N,N,N,N,-tetramethylethylenediamine; In water; at 120 ℃; for 15h;

DOI:10.1016/j.tet.2008.05.072

Reference yield: 52.5%

N1-benzyl-4-methylbenzene-1,2-diamine (39235-93-3) + phenyl chloroformate (1885-14-9) → 1-benzyl-5-methyl-1,3-dihydro-2H-benzo[d]imidazol-2-one (28643-35-8)

Guidance literature:

In 5,5-dimethyl-1,3-cyclohexadiene; Reflux;

DOI:10.1248/cpb.58.918

upstream raw materials:

N¹-benzyl-4-methylbenzene-1,2-diamine

urea

1-benzyl-1-(2-chloro-4-methyl-phenyl)urea

benzyl-(2-chloro-4-methyl-phenyl)-amine

Downstream raw materials:

1-benzyl-2-chloro-5-methyl-1H-benzoimidazole

1-benzyl-5-methyl-1H-benzo[d]imidazole-2(3H)-thione