39235-93-3

Basic information

• Product Name: N¹-benzyl-4-methylbenzene-1,2-diamine
• Synonyms: N¹-benzyl-4-methylbenzene-1,2-diamine
• CAS NO: 39235-93-3
• Molecular Weight: 212.294
• Mol File: 39235-93-3.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: N¹-benzyl-4-methylbenzene-1,2-diamine(CAS DataBase Reference)
• NIST Chemistry Reference: N¹-benzyl-4-methylbenzene-1,2-diamine(39235-93-3)
• EPA Substance Registry System: N¹-benzyl-4-methylbenzene-1,2-diamine(39235-93-3)

Safety Data

• Hazardous Substances Data: 39235-93-3(Hazardous Substances Data)

Upstream product

• 5326-34-1 4-Bromo-3-nitrotoluene 
• 5405-15-2 N-benzyl-N-(4-methylphenyl)amine 
• 100-39-0 benzyl bromide 
• 496-72-0 4-methyl-1,2-diaminobenzene 
• 89-62-3 4-methyl-2-nitroaniline 
• 22019-66-5 4-methyl-2-nitro-N-benzylaniline 
• 100-44-7 benzyl chloride 
• 446-11-7 4-fluoro-3-nitrotoluene 
• 100-46-9 benzylamine 

Downstream Products

• 53811-88-4 1-benzyl-2-furan-2-yl-5-methyl-1H-benzoimidazole 
• 53811-91-9 1-benzyl-2,5-dimethyl-1H-benzoimidazole 
• 53811-77-1 1-benzyl-5-methyl-2-(4-methylphenyl)-1H-benzimidazole 
• 1415650-62-2 1-benzyl-2-(4-(benzyloxy)phenyl)-5-methyl-1H-benzimidazole 
• 2963-65-7 6-methyl-2-phenyl-1H-benzo[d]imidazole 
• 28643-35-8 1-benzyl-5-methyl-1,3-dihydro-2H-benzo[d]imidazol-2-one 
• 55415-32-2 1-benzyl-2-chloro-5-methyl-1H-benzoimidazole 
• 84859-33-6 3-{1-[(E)-2-Benzylamino-5-methyl-phenylimino]-ethyl}-4-hydroxy-6-methyl-pyran-2-one 
• 53811-82-8 2-benzo[1,3]dioxol-5-yl-1-benzyl-5-methyl-1H-benzoimidazole 
• 39235-95-5 1-benzyl-5-methyl-2-phenyl-1H-1,3-benzimidazole 
• 883151-81-3 [1-(2-benzylamino-5-methylphenylcarbamoyl)-2-methylpropyl]carbamic acid tert-butyl ester 

Relevant articles and documents

Suppressive effect of novel aromatic diamine compound on nuclear factor-κB-dependent expression of inducible nitric oxide synthase in macrophages

N1-Benzyl-4-methylbenzene-1,2-diamine (BMD) is a novel synthetic compound. In the present study, BMD compound was discovered to inhibit nitric oxide (NO) production in macrophages RAW 264.7. BMD compound attenuated lipopolysaccharide (LPS)-indu

Discovery and Optimization of Chromone Derivatives as Novel Selective Phosphodiesterase 10 Inhibitors

Phosphodiesterase 10 (PDE10) inhibitors have received much attention as promising therapeutic agents for central nervous system (CNS) disorders such as schizophrenia and Huntington's disease. Recently, a hit compound 1 with a novel chromone scaffold has shown moderate inhibitory activity against PDE10A (IC50 = 500 nM). Hit-to-lead optimization has resulted in compound 3e with an improved inhibitory activity (IC50 = 6.5 nM), remarkable selectivity (>95-fold over other PDEs), and good metabolic stability (RLM t1/2 = 105 min) by using an integrated strategy (molecular modeling, chemical synthesis, bioassay, and cocrystal structure). The cocrystal structural information provides insights into the binding pattern of 3e in the PDE10A catalytic domain to highlight the key role of the halogen and hydrogen bonds toward Tyr524 and Tyr693, respectively, thereby resulting in high selectivity against other PDEs. These new observations are of benefit for the rational design of the next generation PDE10 inhibitors for CNS disorders.

Regioselective Nitration of N-Alkyl Anilines using tert-Butyl Nitrite under Mild Condition

Regioselective ring nitration of N-alkyl anilines is reported using tert-butyl nitrite. The reactions proceed efficiently with a wide range of substrates providing synthetically useful N-nitroso N-alkyl nitroanilines in excellent yields which can be easily converted into N-alkyl phenylenediamines and N-alkyl nitroanilines using Zn-AcOH and HCl/MeOH, respectively.