6-Bromo-1H-indole-3-acetic acid methyl ester

Base Information

• Chemical Name: 6-Bromo-1H-indole-3-acetic acid methyl ester
• CAS No.: 152213-63-3
• Molecular Formula: C10H6BrNO3
• Molecular Weight: 268.11
• Mol file: 152213-63-3.mol

Synonyms:6-Bromo-1H-indole-3-acetic acid methyl ester;1H-INDOLE-3-ACETIC ACID, 6-BROMO-A-OXO-;methyl 2-(6-bromo-1H-indol-3-yl)acetate

Chemical Property of 6-Bromo-1H-indole-3-acetic acid methyl ester

Chemical Property:

• Boiling Point: 394.1±27.0 °C(Predicted)
• PKA: 15.73±0.30(Predicted)
• PSA: 42.09000
• Density: 1.569±0.06 g/cm3(Predicted)
• LogP: 2.64590
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Methyl2-(6-bromo-1H-indol-3-yl)acetate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-Bromo-1H-indole-3-acetic acid methyl ester

There total 10 articles about 6-Bromo-1H-indole-3-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-(6-bromo-1H-indol-3-yl)acetic acid (152213-66-6) + methanol (67-56-1) → (6-bromo-1H-indol-3-yl)acetic acid methyl ester (152213-63-3)

Guidance literature:

With hydrogenchloride; at 20 ℃; for 2h;

DOI:10.1021/ja0659673

Reference yield: 93.0%

methyl (2,6-dibromo-1H-indol-3-yl)acetate (947605-02-9) → (6-bromo-1H-indol-3-yl)acetic acid methyl ester (152213-63-3)

Guidance literature:

With hydrogenchloride; zinc/copper couple; In methanol; water; for 4.5h; Reflux;

DOI:10.1246/cl.2011.1079

Reference yield:

2-(6-bromo-1H-indol-3-yl)acetonitrile (152213-61-1) → (6-bromo-1H-indol-3-yl)acetic acid methyl ester (152213-63-3)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. KOH / methanol / 2 h / 100 °C

2: 98 percent / HCl / 2 h / 20 °C

With hydrogenchloride; potassium hydroxide; In methanol;

DOI:10.1021/ja0659673

upstream raw materials:

2-(6-bromo-1H-indol-3-yl)acetic acid

methanol

2-(6-bromo-1H-indol-3-yl)acetonitrile

6-bromo-1H-indole

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