1-(5-Bromo-2-chloropyridin-3-yl)ethanone

Base Information

• Chemical Name: 1-(5-Bromo-2-chloropyridin-3-yl)ethanone
• CAS No.: 886365-47-5
• Molecular Formula: C₇H₅BrClNO
• Molecular Weight: 234.48
• Hs Code.: 2933399090
• Mol file: 886365-47-5.mol

Synonyms:1-(5-Bromo-2-chloropyridin-3-yl)ethanone;1-(5-bromo-2-chloropyridin-3-yl)ethan-1-one

Chemical Property of 1-(5-Bromo-2-chloropyridin-3-yl)ethanone

Chemical Property:

• Boiling Point: 282.5±40.0 °C(Predicted)
• PKA: -4.03±0.10(Predicted)
• PSA: 29.96000
• Density: 1.647±0.06 g/cm3(Predicted)
• LogP: 2.70010
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98%, ^*data from raw suppliers

1-(5-Bromo-2-chloropyridin-3-yl)ethanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(5-Bromo-2-chloropyridin-3-yl)ethanone

There total 6 articles about 1-(5-Bromo-2-chloropyridin-3-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

5-bromo-2-chloro-N-methoxy-N-methylnicotinamide (885223-63-2) → 1-(5-bromo-2-chloropyridin-3-yl)ethanone (886365-47-5)

Guidance literature:

With methylmagnesium bromide; In tetrahydrofuran; at 0 - 20 ℃; for 0.5h; Inert atmosphere;

DOI:10.1016/j.bmcl.2013.12.112

Reference yield: 90.0%

5-bromo-2-chloro-N-methoxy-N-methylnicotinamide (885223-63-2) + methylmagnesium bromide (75-16-1) → 1-(5-bromo-2-chloropyridin-3-yl)ethanone (886365-47-5)

Guidance literature:

In tetrahydrofuran; at 0 - 20 ℃; for 0.5h; Inert atmosphere;

DOI:10.1016/j.bmcl.2014.07.073

Reference yield: 77.0%

1-(5-bromo-2-chloropyridin-3-yl)ethanol (1111638-41-5) → 1-(5-bromo-2-chloropyridin-3-yl)ethanone (886365-47-5)

Guidance literature:

With pyridine; chromium(VI) oxide; In dichloromethane; at 0 - 20 ℃; Silica gel;

upstream raw materials:

5-bromo-2-chloro-N-methoxy-N-methylnicotinamide

methylmagnesium bromide

1-(5-bromo-2-chloropyridin-3-yl)ethanol

methylmagnesium chloride

Downstream raw materials:

MR⁽⁰³³⁾T₀₀₆₅₉

N-(5-(2-amino-4-methylpyrido[2,3-d]pyrimidin-6-yl)-2-methoxypyridin-3-yl)-2,4-difluorobenzenesulfonamide