878671-95-5

Usage

Uses

Used in Organic Synthesis:
NAPHTHALENE, 1-CYCLOPROPYL-4-ISOTHIOCYANATOis used as a building block for the synthesis of various organic compounds. Its unique structure and functional groups allow for the creation of a wide range of molecules with different properties and potential applications.
Used in Pharmaceutical Chemistry:
NAPHTHALENE, 1-CYCLOPROPYL-4-ISOTHIOCYANATOis used as a starting material or intermediate in the development of new pharmaceutical compounds. Its structure and functional groups can be manipulated to create molecules with specific biological activities, making it a valuable tool in drug discovery and design.

Upstream product

• 25033-19-6 1-cyclopropyl-naphthalene 

Downstream Products

• 878671-98-8 2-((5-amino-4-(4-cyclopropyl-naphthalen-1-yl)-4H-1,2,4-triazol-3-yl)thio)acetic acid methyl ester 
• 878672-00-5 2-{[5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetic acid 
• 878672-00-5 (-)-2-(5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-ylthio)acetic acid 
• 878672-00-5 (+)-2-(5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-ylthio)acetic acid 
• 1533519-86-6 N-(4-cyclopropylnaphthalen-1-yl)-2-formylhydrazine-1-thiocarboxamide 
• 1533519-85-5 2-((4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazole-3-yl)thio)acetic acid methyl ester 
• 1533519-84-4 4-(4-cyclopropylnaphthalen-1-yl)-4Η-1,2,4-triazole-3-thiol 

Relevant academic research and scientific papers

Naphthyl thiocarbonyl compound as well as preparation method and application thereof

The invention provides a naphthyl thiocarbonyl compound of a structural formula I. The invention further provides a preparation method of the compound and application of the compound in preparation ofa lesinurad key intermediate 1-cyclopropylnaphthalene-4-benzyl isothiocyanate of a structural formula VII. The structural formula is as shown in the specification. In the formula, R represents hydroxyl or thio.

Lesinurad analogue and its preparation method and medical use

The invention relates to a lesinurad analog as shown in the general formula (I), its preparation method, a pharmaceutical composition containing the derivative and an application of the pharmaceutical composition used as a therapeutic agent, especially as a medicine for treating hyperuricemia and gout, wherein definition of each substituent group in the general formula (I) is as the same as definition in the specification.

Optically pure thioacetic compound

The invention belongs to the field of pharmacy and relates to an optically pure thioacetic compound and application thereof to medicine. The optically pure thioacetic compound comprises levorotatory 2-(5-bromo-4-(4-cyclopropyl-naphthalene-1-base)-4H-1,2,4-triazole-3-based sulfenyl) acetic acid and dextral 2-(5-bromo-4-(4-cyclopropyl-naphthalene-1-base)-4H-1,2,4-triazole-3-based sulfenyl) acetic acid.

MANUFACTURE OF 2- (5- BROMO-4 (-CYCLOPROPYLNAPHTHALEN-1-YL) -4H-1,2,4-TRIAZOL-3-YLTHIO) ACETIC ACID

Described herein are certain processes for the synthesis of compounds of Formula (I):

POLYMORPHIC, CRYSTALLINE AND MESOPHASE FORMS OF SODIUM 2-(5-BROMO-4-(4-CYCLOPROPYLNAPHTHALEN-1-YL)-4H-1,2,4-TRIAZOL-3-YLTHIO)ACETATE, AND USES THEREOF

Crystalline polymorphs and solid mesophase forms of sodium 2-(5-bromo-4- (4-cyclopropylnaphthalen-l-yl)-4H-l,2,4-triazol-3-ylthio)acetate are described. In addition, pharmaceutical compositions and uses of such compositions for the treatment of a variety of diseases and conditions are provided.