Benzofuran-5-yl-acetic acid Methyl ester

Base Information

• Chemical Name: Benzofuran-5-yl-acetic acid Methyl ester
• CAS No.: 121638-36-6
• Molecular Formula: C11H10O3
• Molecular Weight: 190.199
• Mol file: 121638-36-6.mol

Synonyms:methyl benzofuran-5-ylacetate;5-Benzofuranacetic acid,methyl ester;

Chemical Property of Benzofuran-5-yl-acetic acid Methyl ester

Chemical Property:

• PSA: 39.44000
• LogP: 2.09990

Purity/Quality:

99%+, ^*data from raw suppliers

Methyl2-(Benzofuran-5-yl)acetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzofuran-5-yl-acetic acid Methyl ester

There total 6 articles about Benzofuran-5-yl-acetic acid Methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 4-((2,2-dimethoxy)ethoxy)phenylacetate → methyl 2-(benzofuran-5-yl)acetate (121638-36-6)

Guidance literature:

With polyphosphoric acid; In toluene; at 105 - 110 ℃;

Reference yield:

methanol (67-56-1) + benzofuran-5-yl-acetic acid (142935-60-2) → methyl 2-(benzofuran-5-yl)acetate (121638-36-6)

Guidance literature:

With acetyl chloride; at 20 ℃;

DOI:10.1002/anie.202106109

Reference yield:

4-hydroxyphenylacetate (156-38-7) → methyl 2-(benzofuran-5-yl)acetate (121638-36-6)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium iodide; sodium hydroxide / dimethyl sulfoxide / 50 - 80 °C

2: toluene-4-sulfonic acid / Reflux; Large scale

3: polyphosphoric acid / toluene / 105 - 110 °C

With toluene-4-sulfonic acid; potassium iodide; sodium hydroxide; In dimethyl sulfoxide; toluene;

upstream raw materials:

Methyl 4-hydroxyphenylacetate

Bromoacetaldehyde diethyl acetal

4-hydroxyphenylacetate

methanol

Downstream raw materials:

2,3-dihydrobenzofuran-5-acetic acid

methyl 2-(2,3-dihydrobenzofuran-5-yl)acetate

5-(2-hydroxyethyl)-2,3-dihydrobenzofuran

2,3-dihydro-5-(2-bromoethyl)benzofuran

Refernces

• 1、 -. "Darifenacin intermediate 2, 3 - dihydro - 5 - benzofuran acetic acid preparation new method of (by machine translation)". . . Retrieved 2018/04/03.
• 2、 -. "Monospecific antibodies useful in evaluating inhibition of polymorphonuclear leukocyte elastase by N-substituted azetidinones". . . Retrieved 2008/06/13.