pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4(3H)-one

Base Information

• Chemical Name: pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4(3H)-one
• CAS No.: 55115-79-2
• Molecular Formula: C₉H₅N₃OS
• Molecular Weight: 203.224
• Hs Code.: 2933998090
• Mol file: 55115-79-2.mol

Synonyms:pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4(3H)-one;Pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4(1H)-one

Chemical Property of pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4(3H)-one

Chemical Property:

• PSA: 86.88000
• LogP: 1.53280

Purity/Quality:

99% ^*data from raw suppliers

pyrido[3'',2'':4,5]thieno[3,2-d]pyrimidin-4(3H)-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4(3H)-one

There total 5 articles about pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

formamide (77287-34-4,77287-35-5,60100-09-6) + ethyl 3-aminothieno[2,3-b]pyridine-2-carboxylate (52505-46-1) → Pyrido<3',2':4,5>thieno<3,2-d>pyrimidin-4(1H)-one (55115-79-2)

Guidance literature:

at 135 - 190 ℃; for 5h;

DOI:10.1021/jm9903949

Reference yield: 49.0%

orthoformic acid triethyl ester (122-51-0) + 3-Amino-2-carboxamidothieno<2,3-b>pyridine (55557-48-7) → Pyrido<3',2':4,5>thieno<3,2-d>pyrimidin-4(1H)-one (55115-79-2)

Guidance literature:

for 2h; Heating;

Reference yield:

2-chloro-3-pyridinecarbonitrile (6602-54-6) → Pyrido<3',2':4,5>thieno<3,2-d>pyrimidin-4(1H)-one (55115-79-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: NaH / dimethylsulfoxide / 25 °C

1.2: 89 percent / dimethylsulfoxide / 3 h / 25 °C

2.1: 73 percent / 5 h / 135 - 190 °C

With sodium hydride; In dimethyl sulfoxide; 1.1: Metallation / 1.2: Cyclization / 2.1: Cyclization;

DOI:10.1021/jm9903949

upstream raw materials:

formamide

ethyl 3-aminothieno[2,3-b]pyridine-2-carboxylate

orthoformic acid triethyl ester

3-Amino-2-carboxamidothieno<2,3-b>pyridine

Downstream raw materials:

4-hydrazino-pyrido[3',2':4,5]thieno[3,2-d]pyrimidine

4-chloropyrido[3',2';4,5]thieno[3,2-d]pyrimidine

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