3,5-DIIODOBENZOYL CHLORIDE

Base Information

• Chemical Name: 3,5-DIIODOBENZOYL CHLORIDE
• CAS No.: 42860-25-3
• Molecular Formula: C7H3ClI2O
• Molecular Weight: 392.362
• Mol file: 42860-25-3.mol

Synonyms:3,5-DIIODOBENZOYL CHLORIDE

Chemical Property of 3,5-DIIODOBENZOYL CHLORIDE

Chemical Property:

• Melting Point: 67-68 °C
• Boiling Point: 374.0±32.0 °C(Predicted)
• PSA: 17.07000
• Density: 2.452±0.06 g/cm3(Predicted)
• LogP: 3.27480

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,5-DIIODOBENZOYL CHLORIDE

There total 3 articles about 3,5-DIIODOBENZOYL CHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,5-diiodobenzoic acid (19094-48-5) → 3,5-diiodobenzoyl chloride (42860-25-3)

Guidance literature:

With thionyl chloride;

DOI:10.1021/jo01209a002

Reference yield:

ethyl 3,5-diiodobenzoate (388613-52-3) → 3,5-diiodobenzoyl chloride (42860-25-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / aq. NaOH / ethanol / 2 h / 70 °C

2: thionyl chloride / 2 h / Heating

With sodium hydroxide; thionyl chloride; In ethanol;

DOI:10.1039/b312762a

Reference yield:

2-amino-3,5-diiodobenzoic acid (609-86-9) → 3,5-diiodobenzoyl chloride (42860-25-3)

Guidance literature:

Multi-step reaction with 2 steps

1: aqueous sodium nitrite solution; aqueous hydrochloric acid / Erwaermen des erhaltenen Diazoniumsalzes mit Aethanol unter Zusatz von Kupfer-Pulver

2: thionyl chloride

With hydrogenchloride; thionyl chloride; sodium nitrite;

upstream raw materials:

3,5-diiodobenzoic acid

ethyl 3,5-diiodobenzoate

2-amino-3,5-diiodobenzoic acid

Downstream raw materials:

ethyl 3,5-diiodobenzoate

(S)-N-(1-(diisopropylamino)-4-methyl-1-oxopentan-2-yl)-3,5-diiodobenzamide

2-(2-methoxyethoxy)ethyl-3,5-diiodibenzoate

N-butyl-3,5-diiodobenzamide

Refernces

• 1、 Wang, Qiuhua,Zhong, Yulong,Miller, Daniel P.,Lu, Xiaoxing,Tang, Quan,Lu, Zhong-Lin,Zurek, Eva,Liu, Rui,Gong, Bing. "Self-Assembly and Molecular Recognition in Water: Tubular Stacking and Guest-Templated Discrete Assembly of Water-Soluble, Shape-Persistent Macrocycles". supporting information. p. 2915 - 2924. Retrieved 2020/02/04.
• 2、 Gooyit, Major,Tricoche, Nancy,Lustigman, Sara,Janda, Kim D.. "Dual protonophore-chitinase inhibitors dramatically affect O. Volvulus molting". . p. 5792 - 5799. Retrieved 2014/08/05.