5-(benzyloxy)-2-chloronicotinonitrile

Base Information

Chemical Name:5-(benzyloxy)-2-chloronicotinonitrile
CAS No.:74650-76-3
Molecular Formula:C13H9ClN2O
Molecular Weight:244.68
Hs Code.:

Synonyms:5-(benzyloxy)-2-chloronicotinonitrile

Suppliers and Price of 5-(benzyloxy)-2-chloronicotinonitrile

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-(benzyloxy)-2-chloronicotinonitrile

Chemical Property:

PSA：45.91000
LogP:3.18568

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

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Technology Process of 5-(benzyloxy)-2-chloronicotinonitrile

There total 8 articles about 5-(benzyloxy)-2-chloronicotinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 100-39-0
benzyl bromide

: 74650-75-2
2-chloro-5-hydroxynicotinonitrile

: 74650-76-3
5-benzyloxy-2-chloronicotinonitrile

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; Ambient temperature; overnight;

Reference yield:

2-chloro-5-hydroxy-3-methylpyridine: 54232-03-0
2-chloro-5-hydroxy-3-methylpyridine

: 74650-76-3
5-benzyloxy-2-chloronicotinonitrile

Guidance literature:: Multi-step reaction with 7 steps

1: 95 percent / NaH / dimethylformamide / Ambient temperature; overnight

2: 35 percent / KMnO₄ / H₂O / 1 h / Heating

3: SOCl₂ / 3 h / Heating

4: NH₃*H₂O / 0.25 h / 0 - 4 °C

5: 86 percent / triflic anhydride/triphenylphosphine oxide / CH₂Cl₂ / Ambient temperature; overnight

6: 70 percent / pyridine hydrochloride / 2 h / 200 °C

7: 100 percent / NaH / dimethylformamide / Ambient temperature; overnight

With potassium permanganate; thionyl chloride; trifluoromethylsulfonic anhydride; ammonia; pyridine hydrochloride; sodium hydride; Triphenylphosphine oxide; In dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 74650-70-7
2-chloro-5-methoxy-3-methylpyridine

: 74650-76-3
5-benzyloxy-2-chloronicotinonitrile

Guidance literature:: Multi-step reaction with 6 steps

1: 35 percent / KMnO₄ / H₂O / 1 h / Heating

2: SOCl₂ / 3 h / Heating

3: NH₃*H₂O / 0.25 h / 0 - 4 °C

4: 86 percent / triflic anhydride/triphenylphosphine oxide / CH₂Cl₂ / Ambient temperature; overnight

5: 70 percent / pyridine hydrochloride / 2 h / 200 °C

6: 100 percent / NaH / dimethylformamide / Ambient temperature; overnight

With potassium permanganate; thionyl chloride; trifluoromethylsulfonic anhydride; ammonia; pyridine hydrochloride; sodium hydride; Triphenylphosphine oxide; In dichloromethane; water; N,N-dimethyl-formamide;