2-Chloro-5-methoxy-3-methylpyridine

Base Information

• Chemical Name: 2-Chloro-5-methoxy-3-methylpyridine
• CAS No.: 74650-70-7
• Molecular Formula: C₇H₈ClNO
• Molecular Weight: 157.6
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID90511473
• Wikidata: Q82370266
• Mol file: 74650-70-7.mol

Synonyms:2-Chloro-5-methoxy-3-methylpyridine;74650-70-7;SCHEMBL5942363;DTXSID90511473;GHLYOKOAECDWQL-UHFFFAOYSA-N;ZCA65070;MFCD16610592;AKOS016012925;AB71233;CS-W021660;DS-5171;FT-0714566;C76383;A865842

Chemical Property of 2-Chloro-5-methoxy-3-methylpyridine

Chemical Property:

• Boiling Point: 242.7±35.0 °C(Predicted)
• PKA: -1.77±0.10(Predicted)
• PSA: 22.12000
• Density: 1.168±0.06 g/cm3(Predicted)
• LogP: 2.05200
• Storage Temp.: Inert atmosphere,Room Temperature
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 157.0294416
• Heavy Atom Count: 10
• Complexity: 110

Purity/Quality:

97% ^*data from raw suppliers

2-Chloro-5-methoxy-3-methylpyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=CN=C1Cl)OC

Technology Process of 2-Chloro-5-methoxy-3-methylpyridine

There total 3 articles about 2-Chloro-5-methoxy-3-methylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-chloro-5-hydroxy-3-methylpyridine (54232-03-0) + CH3 I → 2-chloro-5-methoxy-3-methylpyridine (74650-70-7)

Guidance literature:

With NaH; In N,N-dimethyl-formamide;

Reference yield: 95.0%

2-chloro-5-hydroxy-3-methylpyridine (54232-03-0) + methyl iodide (74-88-4) → 2-chloro-5-methoxy-3-methylpyridine (74650-70-7)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; Ambient temperature; overnight;

Reference yield:

6-chloro-5-methylpyridin-3-amine (38186-82-2) → 2-chloro-5-methoxy-3-methylpyridine (74650-70-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.)NaNO₂/12N HCl 2.)HPF₆

2: 95 percent / NaH / dimethylformamide / Ambient temperature; overnight

With hydrogenchloride; hexafluorophosphoric acid; sodium hydride; sodium nitrite; In N,N-dimethyl-formamide;

upstream raw materials:

2-chloro-5-hydroxy-3-methylpyridine

methyl iodide

6-chloro-5-methylpyridin-3-amine

Downstream raw materials:

2-chloro-5-methoxy-3-pyridinecarboxylic acid

(S)-5-benzyloxy-2-(3-t-butylamino-2-hydroxypropoxy)nicotinonitrile

5-benzyloxy-2-chloronicotinonitrile

2-chloro-3-cyano-5-methoxypyridine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 74650-70-7 2-Chloro-5-methoxy-3-methylpyridine

Send

Send

Metric Ton KG G Pound L ML

Send

Send