4-(6-Chloro-pyrimidin-4-yloxy)-piperidine-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:4-(6-Chloro-pyrimidin-4-yloxy)-piperidine-1-carboxylic acid tert-butyl ester
CAS No.:954227-75-9
Molecular Formula:C₁₅H₂₃N₃O₃
Molecular Weight:293.366
Hs Code.:
Mol file:954227-75-9.mol

Synonyms:4-(6-Chloro-pyrimidin-4-yloxy)-piperidine-1-carboxylic acid tert-butyl ester;tert-butyl 4-(6-methylpyrimidin-4-yloxy)piperidine-1-carboxylate

Suppliers and Price of 4-(6-Chloro-pyrimidin-4-yloxy)-piperidine-1-carboxylic acid tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 1 raw suppliers

Chemical Property of 4-(6-Chloro-pyrimidin-4-yloxy)-piperidine-1-carboxylic acid tert-butyl ester

Chemical Property:

Boiling Point:417.3±45.0 °C(Predicted)
PKA:3.61±0.17(Predicted)
PSA：64.55000
Density:1.141±0.06 g/cm3(Predicted)
LogP:2.50120

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 4-(6-Chloro-pyrimidin-4-yloxy)-piperidine-1-carboxylic acid tert-butyl ester

There total 1 articles about 4-(6-Chloro-pyrimidin-4-yloxy)-piperidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 3435-25-4
4-methyl-6-chloropyrimidine

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

: 954227-75-9
tert-butyl 4-[(6-methylpyrimidin-4-yl)oxy]piperidine-1-carboxylate

Guidance literature:: t-butyl 4-hydroxy piperidine-1-carboxylate; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; for 0.5h;

4-methyl-6-chloropyrimidine; In tetrahydrofuran; mineral oil; at 20 ℃; for 24h;

Reference yield:

: 954227-75-9
tert-butyl 4-[(6-methylpyrimidin-4-yl)oxy]piperidine-1-carboxylate

: 1400691-83-9
N-[2-fluoro-5-(trifluoromethyl)phenyl]-1-methyl-3-{4-[(6-methyl-4-pyrimidinyl)oxy]-1-piperidinyl}-1H-1,2,4-triazol-5-amine

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride / methanol / 4 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C

3: isopropyl alcohol / 6 h / Reflux

4: caesium carbonate; XPhos / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / tert-butyl alcohol / 16 h / 100 °C / Inert atmosphere

With hydrogenchloride; caesium carbonate; N-ethyl-N,N-diisopropylamine; XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In methanol; dichloromethane; isopropyl alcohol; tert-butyl alcohol;

Reference yield:

: 954227-75-9
tert-butyl 4-[(6-methylpyrimidin-4-yl)oxy]piperidine-1-carboxylate

: 1400691-97-5
C₁₈H₁₉N₅O₂

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / methanol / 4 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane;