4-Bromo-2-(difluoromethyl)pyridine

Base Information

• Chemical Name: 4-Bromo-2-(difluoromethyl)pyridine
• CAS No.: 1211580-54-9
• Molecular Formula: C6H4BrF2N
• Molecular Weight: 208.005
• Hs Code.: 2933399090
• Mol file: 1211580-54-9.mol

Synonyms:4-Bromo-2-(difluoromethyl)pyridine;4-Bromo-alpha,alpha-difluoro-2-picoline

Chemical Property of 4-Bromo-2-(difluoromethyl)pyridine

Chemical Property:

• Boiling Point: 210.3±35.0 °C(Predicted)
• PKA: 0.27±0.10(Predicted)
• PSA: 12.89000
• Density: 1.640±0.06 g/cm3(Predicted)
• LogP: 2.78170
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

NLT 98% ^*data from raw suppliers

4-Bromo-2-(difluoromethyl)pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Bromo-2-(difluoromethyl)pyridine

There total 1 articles about 4-Bromo-2-(difluoromethyl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

4-bromo-2-pyridinecarboxaldehyde (131747-63-2) → 4-bromo-2-(difluoromethyl)pyridine (1211580-54-9)

Guidance literature:

With diethylamino-sulfur trifluoride; at 20 ℃; for 16h;

Reference yield: 93.0%

5-(3-ethynylphenyl)pyrimidine (872041-35-5) + 4-bromo-2-(difluoromethyl)pyridine (1211580-54-9) → 5-(3-((2-(difluoromethyl)pyridin-4-yl)ethynyl)phenyl)pyrimidine

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 65 ℃; Inert atmosphere;

Reference yield: 92.0%

4-bromo-2-(difluoromethyl)pyridine (1211580-54-9) → 2-(difluoromethyl)pyridin-4-amine (1446509-58-5)

Guidance literature:

With 1-methyl-pyrrolidin-2-one; ammonium hydroxide; copper(II) oxide; at 110 ℃;

upstream raw materials:

4-bromo-2-pyridinecarboxaldehyde

Downstream raw materials:

1-(3-Bromophenyl)-1-(2-(difluoromethyl)pyridin-4-yl)-4-fluoro-1H-isoindol-3-amine

2-(difluoromethyl)isonicotinic acid

methyl 2-(difluoromethyl)isonicotinate

2-(difluoromethyl)pyridin-4-amine

Refernces

• 1、 -. "BACE1 INHIBITORS FOR TREATMENT OF ALZHEIMER'S DISEASE". Page/Page column 33-34. . Retrieved 2019/01/16.
• 2、 -. "SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS". Page/Page column 179. . Retrieved 2016/06/15.