Methyl 2-(difluoroMethyl) isonicotinate

Base Information

• Chemical Name: Methyl 2-(difluoroMethyl) isonicotinate
• CAS No.: 1251844-44-6
• Molecular Formula: C₈H₇F₂NO₂
• Molecular Weight: 187.146
• Hs Code.: 2933399990
• Mol file: 1251844-44-6.mol

Synonyms:Methyl 2-(difluoroMethyl) isonicotinate;Methyl 2-(difluoromethyl)pyridine-4-carboxylate, 2-(Difluoromethyl)-4-(methoxycarbonyl)pyridine;Methyl 2-(difluoroMethyl)pyridine-4-carboxylate;ethyl 2-(difluoroMethyl)isonicotinate

Chemical Property of Methyl 2-(difluoroMethyl) isonicotinate

Chemical Property:

• PSA: 39.19000
• LogP: 1.80580

Purity/Quality:

95% ^*data from raw suppliers

Methyl2-(Difluoromethyl)Isonicotinate ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 2-(difluoroMethyl) isonicotinate

There total 8 articles about Methyl 2-(difluoroMethyl) isonicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

methyl 2-formylpyridine-4-carboxylate (125104-34-9) → methyl 2-(difluoromethyl)isonicotinate (1251844-44-6)

Guidance literature:

methyl 2-formylpyridine-4-carboxylate; With diethylamino-sulfur trifluoride; In dichloromethane; at 0 - 20 ℃; for 2h;

With sodium hydrogencarbonate; In dichloromethane; water; at 0 ℃;

Reference yield: 70.0%

Difluoroacetic acid (381-73-7) + 4-pyridinecarboxylic acid, methyl ester (2459-09-8) → methyl 2-(difluoromethyl)isonicotinate (1251844-44-6)

Guidance literature:

With dipotassium peroxodisulfate; silver nitrate; trifluoroacetic acid; In water; acetonitrile; at 50 ℃; for 24h;

DOI:10.1039/d1md00245g

Reference yield: 62.0%

methyl 2-chloroisonicotinate (58481-11-1) + [1,3-bis[2,6-bis(1-methylethyl)phenyl]-2-imidazolidinylidene](difluoromethyl)silver → methyl 2-(difluoromethyl)isonicotinate (1251844-44-6)

Guidance literature:

With bis[2-(diphenylphosphino)phenyl] ether; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In toluene; at 80 ℃; for 18h; Inert atmosphere;

DOI:10.1039/c7sc00691h

upstream raw materials:

methyl 2-formylpyridine-4-carboxylate

methanol

carbon monoxide

4-bromo-2-(difluoromethyl)pyridine

Downstream raw materials:

2-(difluoromethyl)isonicotinic acid

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