4-Hydroxy-3-methoxy Methamphetamine Hydrochloride

Base Information

• Chemical Name: 4-Hydroxy-3-methoxy Methamphetamine Hydrochloride
• CAS No.: 438625-58-2
• Molecular Formula: C11H18ClNO2
• Molecular Weight: 231.71912
• Mol file: 438625-58-2.mol

Synonyms:4-Hydroxy-3-methoxy Methamphetamine Hydrochloride;2-Methoxy-4-[2-(MethylaMino)propyl]phenol Hydrochloride;HMMA (hydrochloride)

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Chemical Property of 4-Hydroxy-3-methoxy Methamphetamine Hydrochloride

Chemical Property:

• PSA: 41.49000
• LogP: 2.74410

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: HMMA (hydrochloride) (Item No. 14195) is an analytical reference standard that is classified as an amphetamine. It is a phase 2 metabolite of 3,4-MDMA and is typically glucuronidated or sulfated before excretion and detected in urine after cleavage, although intact forms may also be measured. This product is intended for forensic and research purposes.

Technology Process of 4-Hydroxy-3-methoxy Methamphetamine Hydrochloride

There total 4 articles about 4-Hydroxy-3-methoxy Methamphetamine Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

1-(4-hydroxy-3-methoxyphenyl)2-propanone (2503-46-0) + sodium cyanoborohydride (25895-60-7) → (+/-)-4-Hydroxy-3-methoxymethamphetamine hydrochloride (438625-58-2)

Guidance literature:

With hydrogenchloride; methylamine; In methanol; at 20 ℃; for 24h; pH=6; Inert atmosphere;

DOI:10.1248/cpb.57.472

Reference yield: 24.0%

1-(4-hydroxy-3-methoxyphenyl)2-propanone (2503-46-0) + methylamine hydrochloride (593-51-1) → (+/-)-4-Hydroxy-3-methoxymethamphetamine hydrochloride (438625-58-2)

Guidance literature:

1-(4-hydroxy-3-methoxyphenyl)2-propanone; methylamine hydrochloride; In methanol; at 20 ℃; for 3.5h;

With hydrogenchloride; sodium cyanoborohydride; In methanol; at 20 ℃; for 48h; pH=4 - 6; Further stages.;

DOI:10.1038/sj.bjp.0707473

Reference yield:

[2-(3,4-Bis-benzyloxy-phenyl)-1-methyl-ethyl]-methyl-((S)-1-phenyl-ethyl)-amine; hydrochloride → (S)-4-hydroxy-3-methoxymethamphetamine hydrochloride (438625-58-2) + (R)-4-hydroxy-3-methoxymethamphetamine hydrochloride (438625-58-2)

Guidance literature:

With hydrogen; palladium on activated charcoal; In dichloromethane; at 20 ℃; for 24h; under 2250.18 Torr; Title compound not separated from byproducts;

DOI:10.1016/S0968-0896(01)00367-4

upstream raw materials:

1-(4-hydroxy-3-methoxyphenyl)2-propanone

methylamine hydrochloride

sodium cyanoborohydride

Refernces

• 1、 Montgomery,Buon,Eibauer,Guiry,Keenan,McBean. "Comparative potencies of 3,4-methylenedioxymethamphetamine (MDMA) analogues as inhibitors of [3H]noradrenaline and [3H]5-HT transport in mammalian cell lines". . p. 1121 - 1130. Retrieved 2008/03/13.