Methyl 2,3-difluoro-4-hydroxybenzoate

Base Information

• Chemical Name: Methyl 2,3-difluoro-4-hydroxybenzoate
• CAS No.: 219685-84-4
• Molecular Formula: C8H6F2O3
• Molecular Weight: 188.131
• Hs Code.: 2918290090
• Mol file: 219685-84-4.mol

Synonyms:Methyl 2,3-difluoro-4-hydroxybenzoate

Chemical Property of Methyl 2,3-difluoro-4-hydroxybenzoate

Chemical Property:

• Melting Point: 138 - 140 °C
• Boiling Point: 282.5±40.0 °C(Predicted)
• PKA: 6.12±0.23(Predicted)
• PSA: 46.53000
• Density: 1.402±0.06 g/cm3(Predicted)
• LogP: 1.45700

Purity/Quality:

99% ^*data from raw suppliers

Methyl2,3-difluoro-4-hydroxybenzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Methyl 2,3-difluoro-4-hydroxybenzoate

There total 1 articles about Methyl 2,3-difluoro-4-hydroxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methanol (67-56-1) + 2,3-difluoro-4-hydroxybenzoic acid (175968-39-5) → methyl 2,3-difluoro-4-hydroxybenzoate (219685-84-4)

Guidance literature:

With hydrogenchloride; In water; for 24h; Reflux;

DOI:10.1002/cmdc.201300015

Reference yield: 94.0%

methyl 2,3-difluoro-4-hydroxybenzoate (219685-84-4) → 2,3-difluoro-4-(hydroxymethyl)phenol (1472068-00-0)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 0.75h;

DOI:10.1002/cmdc.201300015

Reference yield: 84.0%

methyl 2,3-difluoro-4-hydroxybenzoate (219685-84-4) + cyclopropylcarbinyl bromide (7051-34-5) → 4-cyclopropylmethoxy-2,3-difluoro-benzoic acid methyl ester (1040724-06-8)

Guidance literature:

methyl 2,3-difluoro-4-hydroxybenzoate; With potassium carbonate; sodium iodide; In acetone; at 20 ℃; for 0.5h;

cyclopropylcarbinyl bromide; In acetone; for 48h; Heating / reflux;

upstream raw materials:

methanol

2,3-difluoro-4-hydroxybenzoic acid

Downstream raw materials:

2,3-Difluoro-4-(2-fluorooctyloxy)benzoic acid

4-cyclopropylmethoxy-2,3-difluoro-benzoic acid methyl ester

4-[(2,3-difluoro-4-hydroxybenzyl)(4H-1,2,4-triazol-4-yl)amino]-benzonitrile

2,3-difluoro-4-(hydroxymethyl)phenol

Refernces

• 1、 -. "SYNTHESIS OF PYRAZOLES". Page/Page column 53. . Retrieved 2009/08/16.