benzyl 5-(1-(tert-butoxycarbonyl)piperidine-4-yloxy)-3,3-dimethyl-3,4-dihydroisoquinoline-2(1H)-carboxylate

Base Information

Chemical Name:benzyl 5-(1-(tert-butoxycarbonyl)piperidine-4-yloxy)-3,3-dimethyl-3,4-dihydroisoquinoline-2(1H)-carboxylate
CAS No.:1430564-02-5
Molecular Formula:C₂₉H₃₈N₂O₅
Molecular Weight:0
Hs Code.:
Mol file:1430564-02-5.mol

Synonyms:benzyl 5-(1-(tert-butoxycarbonyl)piperidine-4-yloxy)-3,3-dimethyl-3,4-dihydroisoquinoline-2(1H)-carboxylate

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Chemical Property of benzyl 5-(1-(tert-butoxycarbonyl)piperidine-4-yloxy)-3,3-dimethyl-3,4-dihydroisoquinoline-2(1H)-carboxylate

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Technology Process of benzyl 5-(1-(tert-butoxycarbonyl)piperidine-4-yloxy)-3,3-dimethyl-3,4-dihydroisoquinoline-2(1H)-carboxylate

There total 10 articles about benzyl 5-(1-(tert-butoxycarbonyl)piperidine-4-yloxy)-3,3-dimethyl-3,4-dihydroisoquinoline-2(1H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1430564-01-4
benzyl 5-hydroxy-3,3-dimethyl-3,4-dihydroisoquinoline-2(1H)-carboxylate

: 141699-59-4
1-(tert-butoxycarbonyl)piperidin-4-yl methanesulfonate

: 1430564-02-5
benzyl 5-(1-(tert-butoxycarbonyl)piperidine-4-yloxy)-3,3-dimethyl-3,4-dihydroisoquinoline-2(1H)-carboxylate

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 85 ℃; for 18h;

Reference yield:

: 1430115-67-5
benzyl 5-bromo-3,3-dimethyl-3,4-dihydroisoquinoline-2(1H)-carboxylate

: 1430564-02-5
benzyl 5-(1-(tert-butoxycarbonyl)piperidine-4-yloxy)-3,3-dimethyl-3,4-dihydroisoquinoline-2(1H)-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 18 h / 85 °C / Inert atmosphere

2: sodium perborate / tetrahydrofuran; water / 4 h / 50 °C

3: caesium carbonate / N,N-dimethyl-formamide / 18 h / 85 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium perborate; potassium carbonate; caesium carbonate; In tetrahydrofuran; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 1430564-00-3
benzyl 3,3-dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

: 1430564-02-5
benzyl 5-(1-(tert-butoxycarbonyl)piperidine-4-yloxy)-3,3-dimethyl-3,4-dihydroisoquinoline-2(1H)-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium perborate / tetrahydrofuran; water / 4 h / 50 °C

2: caesium carbonate / N,N-dimethyl-formamide / 18 h / 85 °C

With sodium perborate; caesium carbonate; In tetrahydrofuran; water; N,N-dimethyl-formamide;