benzyl 5-hydroxy-3,3-dimethyl-3,4-dihydroisoquinoline-2(1H)-carboxylate

Base Information

Chemical Name:benzyl 5-hydroxy-3,3-dimethyl-3,4-dihydroisoquinoline-2(1H)-carboxylate
CAS No.:1430564-01-4
Molecular Formula:C₁₉H₂₁NO₃
Molecular Weight:311.381
Hs Code.:

Synonyms:benzyl 5-hydroxy-3,3-dimethyl-3,4-dihydroisoquinoline-2(1H)-carboxylate

Suppliers and Price of benzyl 5-hydroxy-3,3-dimethyl-3,4-dihydroisoquinoline-2(1H)-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of benzyl 5-hydroxy-3,3-dimethyl-3,4-dihydroisoquinoline-2(1H)-carboxylate

Chemical Property:

Purity/Quality:: 98%min ^*data from raw suppliers

Safty Information:

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Technology Process of benzyl 5-hydroxy-3,3-dimethyl-3,4-dihydroisoquinoline-2(1H)-carboxylate

There total 9 articles about benzyl 5-hydroxy-3,3-dimethyl-3,4-dihydroisoquinoline-2(1H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1430564-00-3
benzyl 3,3-dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

: 1430564-01-4
benzyl 5-hydroxy-3,3-dimethyl-3,4-dihydroisoquinoline-2(1H)-carboxylate

Guidance literature:: With sodium perborate; In tetrahydrofuran; water; at 50 ℃; for 4h;

Reference yield:

: 1430115-67-5
benzyl 5-bromo-3,3-dimethyl-3,4-dihydroisoquinoline-2(1H)-carboxylate

: 1430564-01-4
benzyl 5-hydroxy-3,3-dimethyl-3,4-dihydroisoquinoline-2(1H)-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 18 h / 85 °C / Inert atmosphere

2: sodium perborate / tetrahydrofuran; water / 4 h / 50 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium perborate; potassium carbonate; In tetrahydrofuran; water; dimethyl sulfoxide;

Reference yield:

: 1401437-29-3
1-bromo-2-(2-isocyanato-2-methylpropyl)benzene

: 1430564-01-4
benzyl 5-hydroxy-3,3-dimethyl-3,4-dihydroisoquinoline-2(1H)-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: sodium hydride / tetrahydrofuran; mineral oil / 3 h / 0 - 20 °C

2: acetic acid; sulfuric acid / 48 h / 0 - 20 °C

3: potassium hydroxide; water / ethylene glycol / 72 h / 150 °C

4: sodium hydroxide / tetrahydrofuran; water / 48 h / 0 °C

5: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 18 h / 85 °C / Inert atmosphere

6: sodium perborate / tetrahydrofuran; water / 4 h / 50 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium perborate; sulfuric acid; water; sodium hydride; potassium carbonate; acetic acid; potassium hydroxide; sodium hydroxide; In tetrahydrofuran; water; ethylene glycol; dimethyl sulfoxide; mineral oil;