Technology Process of benzyl 3,3-dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydroisoquinoline-2(1H)-carboxylate
There total 8 articles about benzyl 3,3-dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydroisoquinoline-2(1H)-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate;
In
dimethyl sulfoxide;
at 85 ℃;
for 18h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: sodium hydride / tetrahydrofuran; mineral oil / 3 h / 0 - 20 °C
2: acetic acid; sulfuric acid / 48 h / 0 - 20 °C
3: potassium hydroxide; water / ethylene glycol / 72 h / 150 °C
4: sodium hydroxide / tetrahydrofuran; water / 48 h / 0 °C
5: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 18 h / 85 °C / Inert atmosphere
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sulfuric acid; water; sodium hydride; potassium carbonate; acetic acid; potassium hydroxide; sodium hydroxide;
In
tetrahydrofuran; water; ethylene glycol; dimethyl sulfoxide; mineral oil;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: potassium hydroxide / ethylene glycol / 48 h / 150 °C
2: triethylamine; diphenyl phosphoryl azide / toluene / 4.75 h / 0 °C / Reflux
3: sodium hydride / tetrahydrofuran; mineral oil / 3 h / 0 - 20 °C
4: acetic acid; sulfuric acid / 48 h / 0 - 20 °C
5: potassium hydroxide; water / ethylene glycol / 72 h / 150 °C
6: sodium hydroxide / tetrahydrofuran; water / 48 h / 0 °C
7: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 18 h / 85 °C / Inert atmosphere
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sulfuric acid; diphenyl phosphoryl azide; water; sodium hydride; potassium carbonate; acetic acid; triethylamine; potassium hydroxide; sodium hydroxide;
In
tetrahydrofuran; water; ethylene glycol; dimethyl sulfoxide; toluene; mineral oil;
