2-(2-Aminopyridin-3-yl)acetic acid

Base Information

• Chemical Name: 2-(2-Aminopyridin-3-yl)acetic acid
• CAS No.: 101860-97-3
• Molecular Formula: C₇H₈N₂O₂
• Molecular Weight: 152.153
• Hs Code.: 2933399090
• ChEMBL ID: CHEMBL3322869
• DSSTox Substance ID: DTXSID201307332
• Mol file: 101860-97-3.mol

Synonyms:2-(2-Aminopyridin-3-yl)acetic acid;101860-97-3;61494-61-9;(2-AMINO-PYRIDIN-3-YL)-ACETIC ACID;2-(2-aminopyridin-3-yl)aceticacid;3-Pyridineacetic acid, 2-amino-;2-(2-Amino-3-pyridyl)acetic Acid;2-aminopyridyl acetic acid;2-amino-3-pyridineacetic acid;SCHEMBL2491261;CHEMBL3322869;DTXSID201307332;BCP31910;(2-Amino-pyridin-3-yl)-aceticacid;MFCD11848318;ZB1103;AKOS013452244;CS-W021378;SB21200;SB40389;AM806598;DS-17068;EN300-177877;A897030;2-[(4-Fluorophenyl)amino]-3-pyridineacetic acid pound>>(2-Amino-pyridin-3-yl)-acetic acid

Chemical Property of 2-(2-Aminopyridin-3-yl)acetic acid

Chemical Property:

• Melting Point: 219-221.5℃ (decomposition)
• Boiling Point: 379.2±27.0 °C(Predicted)
• PKA: 3.50±0.10(Predicted)
• PSA: 76.21000
• Density: 1.353±0.06 g/cm3(Predicted)
• LogP: 0.87210
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: 0
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 152.058577502
• Heavy Atom Count: 11
• Complexity: 149

Purity/Quality:

97% ^*data from raw suppliers

2-(2-Aminopyridin-3-yl)aceticAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(N=C1)N)CC(=O)O

Technology Process of 2-(2-Aminopyridin-3-yl)acetic acid

There total 10 articles about 2-(2-Aminopyridin-3-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

3-(2-trimetylacetylamino)pyridylacetic acid (1071087-00-7) → 7-azaoxindole (5654-97-7) + 2-amino-3-pyridylacetic acid (101860-97-3)

Guidance literature:

With hydrogenchloride; Reflux;

DOI:10.1016/j.bmc.2013.11.031

Reference yield:

3-(2-trimetylacetylamino)pyridylacetic acid (1071087-00-7) → 2-amino-3-pyridylacetic acid (101860-97-3)

Guidance literature:

With hydrogenchloride; Heating;

DOI:10.1021/jm00172a004

Reference yield:

n-butyllithium-hexane + dry ice powder + 2,2-dimethyl-N-(3-methylpyridin-2-yl)propionamide (86847-66-7) → 2-amino-3-pyridylacetic acid (101860-97-3)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; diethyl ether; water;

upstream raw materials:

2-(2-chloropyridin-3-yl)acetonitrile

3-(2-trimetylacetylamino)pyridylacetic acid

copper(II) sulfate

3-methylpyridin-2-ylamine

Downstream raw materials:

7-azaoxindole