N-(3-methylpyridin-2-yl)pivalamide

Base Information

• Chemical Name: N-(3-methylpyridin-2-yl)pivalamide
• CAS No.: 86847-66-7
• Molecular Formula: C11H16N2O
• Molecular Weight: 192.261
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID10363173
• Wikidata: Q82146762
• Mol file: 86847-66-7.mol

Synonyms:86847-66-7;N-(3-methylpyridin-2-yl)pivalamide;N-(3-Methyl-2-pyridinyl)-2,2-dimethylpropanamide;2,2-dimethyl-N-(3-methylpyridin-2-yl)propanamide;2,2-dimethyl-N-(3-methyl-2-pyridinyl)propanamide;Bionet2_001414;SCHEMBL2494002;DTXSID10363173;HMS1368A06;MFCD00495372;AKOS003870397;AM81030;SB54871;CS-0330778;FT-0760751

Chemical Property of N-(3-methylpyridin-2-yl)pivalamide

Chemical Property:

• Melting Point: 85-88℃ (hexane )
• PSA: 41.99000
• LogP: 2.44760
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 192.126263138
• Heavy Atom Count: 14
• Complexity: 208

Purity/Quality:

98%Min ^*data from raw suppliers

N-(3-Methyl-2-pyridinyl)-2,2-dimethylpropanamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(N=CC=C1)NC(=O)C(C)(C)C

Technology Process of N-(3-methylpyridin-2-yl)pivalamide

There total 4 articles about N-(3-methylpyridin-2-yl)pivalamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.8%

3-methylpyridin-2-ylamine (1603-40-3) + pivaloyl chloride (3282-30-2) → 2,2-dimethyl-N-(3-methylpyridin-2-yl)propionamide (86847-66-7)

Guidance literature:

With triethylamine; In tetrahydrofuran; hexane; acetone;

Reference yield:

2-(pivaloylamino)pyridine (86847-59-8) + methyl iodide (74-88-4) → 2,2-dimethyl-N-(3-methylpyridin-2-yl)propionamide (86847-66-7)

Guidance literature:

With n-butyllithium; Yield given. Multistep reaction; THF, hexane, 1) 0 degC, 4h, 2) -78 deg C to room temp.;

DOI:10.1021/jo00168a007

Reference yield:

2-aminopyridine (504-29-0) → 2,2-dimethyl-N-(3-methylpyridin-2-yl)propionamide (86847-66-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 79 percent / triethylamine / CH₂Cl₂ / 2 h / Ambient temperature

2: n-BuLi / THF, hexane, 1) 0 degC, 4h, 2) -78 deg C to room temp.

With n-butyllithium; triethylamine; In dichloromethane;

DOI:10.1021/jo00168a007

upstream raw materials:

3-methylpyridin-2-ylamine

pivaloyl chloride

2-(pivaloylamino)pyridine

methyl iodide

Downstream raw materials:

2-t-Butyl<1H>-pyrrolo<2,3-b>pyridine

7-Azaindole

7-azaoxindole

2-amino-3-pyridylacetic acid