6-Bromo-4-methoxy-2,2'-bipyridine

Base Information

Chemical Name:6-Bromo-4-methoxy-2,2'-bipyridine
CAS No.:205052-93-3
Molecular Formula:C₁₁H₉BrN₂O
Molecular Weight:265.109
Hs Code.:
DSSTox Substance ID:DTXSID60443494
Wikidata:Q82261358
Mol file:205052-93-3.mol

Synonyms:6-BROMO-4-METHOXY-2,2'-BIPYRIDINE;205052-93-3;SCHEMBL1366769;DTXSID60443494;J-400778

Suppliers and Price of 6-Bromo-4-methoxy-2,2'-bipyridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
6-BROMO-4-METHOXY-2,2'-BIPYRIDINE 95.00%
5MG
$ 503.58

Total 1 raw suppliers

Chemical Property of 6-Bromo-4-methoxy-2,2'-bipyridine

Chemical Property:

Boiling Point:351.073oC at 760 mmHg
Flash Point:166.124oC
PSA：35.01000
Density:1.462g/cm3
LogP:2.91470
XLogP3:2.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:263.98983
Heavy Atom Count:15
Complexity:203

Purity/Quality:: 6-BROMO-4-METHOXY-2,2'-BIPYRIDINE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=CC(=NC(=C1)Br)C2=CC=CC=N2

Technology Process of 6-Bromo-4-methoxy-2,2'-bipyridine

There total 10 articles about 6-Bromo-4-methoxy-2,2'-bipyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 117873-72-0
2,6-dibromo-4-methoxy pyridine

: phenyl(pyridin-2-yl)(p-tolyl)sulfonium trifluoromethanesulfonate

: 205052-93-3
6-bromo-4-methoxy-2,2'-bipyridine

Guidance literature:: 2,6-dibromo-4-methoxy pyridine; With TurboGrignard; In tetrahydrofuran; at 45 ℃; for 2h; Sealed tube; Inert atmosphere;

phenyl(pyridin-2-yl)(p-tolyl)sulfonium trifluoromethanesulfonate; In tetrahydrofuran; at 30 ℃; for 2h; Sealed tube; Inert atmosphere;
DOI:10.1021/acs.orglett.1c03379

Reference yield: 90.0%

: 205052-91-1
6-bromo-4-methoxy-2,2'-bipyridine N-oxide

: 205052-93-3
6-bromo-4-methoxy-2,2'-bipyridine

Guidance literature:: With phosphorus tribromide; In chloroform; for 0.75h; Heating;
DOI:10.1021/jo972022i

Reference yield:

: 366-18-7
[2,2]bipyridinyl

: 205052-93-3
6-bromo-4-methoxy-2,2'-bipyridine

Guidance literature:: Multi-step reaction with 5 steps

1.1: 79 percent / m-CPBA / CHCl₃ / 13 h / 25 °C

2.1: 65 percent / KNO₃; H₂SO₄ / 2.5 h / 110 °C

3.1: 88 percent / methanol / 0.5 h / 40 °C

4.1: LDA / hexane; tetrahydrofuran / 1 h / -70 °C

4.2: 15 percent / BrCN / hexane; tetrahydrofuran / 0.25 h / -70 °C

5.1: 90 percent / PBr₃ / CHCl₃ / 0.75 h / Heating

With sulfuric acid; phosphorus tribromide; potassium nitrate; 3-chloro-benzenecarboperoxoic acid; lithium diisopropyl amide; In tetrahydrofuran; methanol; hexane; chloroform; 1.1: Oxidation / 2.1: Nitration / 3.1: Substitution / 4.1: Metallation / 4.2: Bromination / 5.1: Reduction;
DOI:10.1021/jo972022i