Technology Process of 6-Bromo-4-methoxy-2,2'-bipyridine
There total 10 articles about 6-Bromo-4-methoxy-2,2'-bipyridine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2,6-dibromo-4-methoxy pyridine;
With
TurboGrignard;
In
tetrahydrofuran;
at 45 ℃;
for 2h;
Sealed tube;
Inert atmosphere;
phenyl(pyridin-2-yl)(p-tolyl)sulfonium trifluoromethanesulfonate;
In
tetrahydrofuran;
at 30 ℃;
for 2h;
Sealed tube;
Inert atmosphere;
DOI:10.1021/acs.orglett.1c03379
- Guidance literature:
-
With
phosphorus tribromide;
In
chloroform;
for 0.75h;
Heating;
DOI:10.1021/jo972022i
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 79 percent / m-CPBA / CHCl3 / 13 h / 25 °C
2.1: 65 percent / KNO3; H2SO4 / 2.5 h / 110 °C
3.1: 88 percent / methanol / 0.5 h / 40 °C
4.1: LDA / hexane; tetrahydrofuran / 1 h / -70 °C
4.2: 15 percent / BrCN / hexane; tetrahydrofuran / 0.25 h / -70 °C
5.1: 90 percent / PBr3 / CHCl3 / 0.75 h / Heating
With
sulfuric acid; phosphorus tribromide; potassium nitrate; 3-chloro-benzenecarboperoxoic acid; lithium diisopropyl amide;
In
tetrahydrofuran; methanol; hexane; chloroform;
1.1: Oxidation / 2.1: Nitration / 3.1: Substitution / 4.1: Metallation / 4.2: Bromination / 5.1: Reduction;
DOI:10.1021/jo972022i