2,6-Dibromo-4-methoxypyridine

Base Information

• Chemical Name: 2,6-Dibromo-4-methoxypyridine
• CAS No.: 117873-72-0
• Molecular Formula: C6H5 Br2 N O
• Molecular Weight: 266.92
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID40447778
• Nikkaji Number: J819.692C
• Mol file: 117873-72-0.mol

Synonyms:2,6-DIBROMO-4-METHOXYPYRIDINE;117873-72-0;2,6-dibromo-4-methoxy-pyridine;Pyridine, 2,6-dibromo-4-methoxy-;MFCD11036227;SCHEMBL1424963;2,6-dibromo-4-methoxy pyridine;DTXSID40447778;FBLLPCQLOGKHAL-UHFFFAOYSA-N;BCP10088;BBL101184;STL554980;AKOS005257289;CS-W019246;DS-2887;SB21170;AC-28009;SY105553;AM20050695;FT-0697382;F11647;AC-907/34104049;W-204963

Chemical Property of 2,6-Dibromo-4-methoxypyridine

Chemical Property:

• Vapor Pressure: 0.00556mmHg at 25°C
• Melting Point: 136 °C(Solv: ethanol (64-17-5); water (7732-18-5))
• Refractive Index: 1.582
• Boiling Point: 283°Cat760mmHg
• PKA: -2.35±0.10(Predicted)
• Flash Point: 124.9°C
• PSA: 22.12000
• Density: 1.919g/cm³
• LogP: 2.61520
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 2.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 266.87174
• Heavy Atom Count: 10
• Complexity: 102

Purity/Quality:

97% ^*data from raw suppliers

2,6-Dibromo-4-methoxypyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC(=NC(=C1)Br)Br
• Uses: 2,6-Dibromo-4-methoxypyridine is a useful reactant for the preparation of various organic compounds such as pyridine-pyridone alternate oligomers, and cyclic adenosine monophosphate.

Technology Process of 2,6-Dibromo-4-methoxypyridine

There total 4 articles about 2,6-Dibromo-4-methoxypyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

methanol (67-56-1) + 2,6-dibromo-4-nitropyridine (175422-04-5) → 2,6-dibromo-4-methoxy pyridine (117873-72-0)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 20 ℃; for 2h;

Reference yield: 92.0%

sodium methylate (124-41-4) + 2,6-dibromo-4-nitropyridine (175422-04-5) → 2,6-dibromo-4-methoxy pyridine (117873-72-0)

Guidance literature:

In tetrahydrofuran; at 40 ℃; for 44h;

DOI:10.1002/hlca.19970800108

Reference yield:

2,6-dibromo-4-nitropyridine (175422-04-5) → 2,6-dibromo-4-methoxy pyridine (117873-72-0)

Guidance literature:

In tetrahydrofuran; methanol; mineral oil;

upstream raw materials:

sodium methylate

2,6-dibromo-4-nitropyridine

2,4,6-tribromopyridine

methanol

Downstream raw materials:

6-bromo-4-methoxy-2,2'-bipyridine

6-bromo-4-methoxypyridin-2-amine

2-bromo-4-methoxy-6-{3-(trifluoromethoxy)phenoxy} pyridine

2-bromo-4-methoxy-6-[3-(trifluoromethyl)phenoxy] pyridine