5-DIMETHOXYMETHYL-TETRAHYDRO-FURAN-3-OL

Base Information

• Chemical Name: 5-DIMETHOXYMETHYL-TETRAHYDRO-FURAN-3-OL
• CAS No.: 127682-76-2
• Molecular Formula: C7H14O4
• Molecular Weight: 162.18
• Mol file: 127682-76-2.mol

Synonyms:5-DIMETHOXYMETHYL-TETRAHYDRO-FURAN-3-OL;(3R,5R)-5-(diMethoxyMethyl)tetrahydrofuran-3-ol

Chemical Property of 5-DIMETHOXYMETHYL-TETRAHYDRO-FURAN-3-OL

Chemical Property:

• PSA: 47.92000
• LogP: -0.24490

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-DIMETHOXYMETHYL-TETRAHYDRO-FURAN-3-OL

There total 10 articles about 5-DIMETHOXYMETHYL-TETRAHYDRO-FURAN-3-OL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

methanol (67-56-1) + 3-deoxy-1,2-O-(1-methylethylidene)-α-D-erythro-pentofuranose 4-methylbenzenesufonate (3396-72-3) → (2R,4S)-4-hydroxy-2-dimethoxymethyltetrahydrofuran (127682-76-2)

Guidance literature:

With acetic acid;

DOI:10.1016/S0040-4039(01)93867-5

Reference yield: 74.0%

(1R,2R,5R)-2-(dimethoxymethyl)-3,6-dioxabicyclo[3.1.0]hexane (89860-19-5) → (2R,4S)-4-hydroxy-2-dimethoxymethyltetrahydrofuran (127682-76-2) + (2R,3R)-3-hydroxy-2-dimethoxymethyltetrahydrofuran (161855-32-9)

Guidance literature:

With diisobutylaluminium hydride; In dichloromethane; toluene; at 0 ℃; for 6h; regioselective reaction;

DOI:10.1002/chem.201101855

Reference yield:

methanol (67-56-1) + 3-deoxy-1,2-O-(1-methylethylidene)-α-D-erythro-pentofuranose 4-methylbenzenesufonate (3396-72-3) → (3R,5S)-5-Dimethoxymethyl-tetrahydro-furan-3-ol (127682-76-2)

Guidance literature:

With acetic acid; at 70 ℃; for 72h;

DOI:10.1021/jm00091a001

upstream raw materials:

methanol

3-deoxy-1,2-O-(1-methylethylidene)-α-D-erythro-pentofuranose 4-methylbenzenesufonate

(1R,2R,5R)-2-(dimethoxymethyl)-3,6-dioxabicyclo[3.1.0]hexane

D-xylofuranose

Downstream raw materials:

(2R-cis)-4-aminotetrahydro-2-furanmethanol

(2R-trans)-tetrahydro-4-<<(4-methylphenyl)sulfonyl>oxy>-2-furanmethanol

(2R-cis)-4-(6-chloro-9H-purin-9-yl)tetrahydrofuran-2-methanol

(3S-trans)-tetrahydro-5-(dimethoxymethyl)-3-furanol 4-methylbenzenesulfonate