(1S,2R)-2'-OXOSPIRO[CYCLOPROPANE-1,3'-INDOLINE]-2-CARBONITRILE

Base Information

• Chemical Name: (1S,2R)-2'-OXOSPIRO[CYCLOPROPANE-1,3'-INDOLINE]-2-CARBONITRILE
• CAS No.: 895576-37-1
• Molecular Formula: C₁₂H₁₀N₂O
• Molecular Weight: 198.224
• Mol file: 895576-37-1.mol

Synonyms:(1S,2R)-2'-OXOSPIRO[CYCLOPROPANE-1,3'-INDOLINE]-2-CARBONITRILE

Chemical Property of (1S,2R)-2'-OXOSPIRO[CYCLOPROPANE-1,3'-INDOLINE]-2-CARBONITRILE

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S,2R)-2'-OXOSPIRO[CYCLOPROPANE-1,3'-INDOLINE]-2-CARBONITRILE

There total 8 articles about (1S,2R)-2'-OXOSPIRO[CYCLOPROPANE-1,3'-INDOLINE]-2-CARBONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

(1-methyl-2-oxo-2,3-dihydro-1H-indol-3-yl)acetonitrile (99984-61-9,70351-50-7) + 1,1-dibromomethane (74-95-3) → spiro[cyclopropane-1,3'-[3H]indole]-1',2'-dihydro-1'-methyl-2'-oxo-2-nitrile (895576-37-1,895576-36-0) + spiro[cyclopropane-1,3'-[3H]indole]-1',2'-dihydro-1'-methyl-2'-oxo-2-nitrile (895576-37-1,895576-36-0)

Guidance literature:

(1-methyl-2-oxo-2,3-dihydro-1H-indol-3-yl)acetonitrile; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.0833333h;

1,1-dibromomethane; In N,N-dimethyl-formamide; at 20 ℃; for 5h; optical yield given as %de;

DOI:10.1016/j.tet.2012.06.025

Reference yield: 61.0%

(1-methyl-2-oxo-2,3-dihydro-1H-indol-3-yl)acetonitrile (99984-61-9,70351-50-7) + 1,1-dibromomethane (74-95-3) → spiro[cyclopropane-1,3'-[3H]indole]-1',2'-dihydro-1'-methyl-2'-oxo-2-nitrile (895576-37-1,895576-36-0) + spiro[cyclopropane-1,3'-[3H]indole]-1',2'-dihydro-1'-methyl-2'-oxo-2-nitrile (895576-37-1,895576-36-0)

Guidance literature:

(1-methyl-2-oxo-2,3-dihydro-1H-indol-3-yl)acetonitrile; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.0833333h;

1,1-dibromomethane; In N,N-dimethyl-formamide; at 20 ℃; for 5h; optical yield given as %de;

DOI:10.1016/j.tet.2012.06.025

Reference yield: 51.0%

(1-methyl-2-oxo-2,3-dihydro-1H-indol-3-yl)acetonitrile (99984-61-9,70351-50-7) + 1,1-dibromomethane (74-95-3) → (1-methyl-3-hydroxy-2-oxo-2,3-dihydroindol-3-yl)acetonitrile (885117-65-7) + C12H10N2OHBr + 1'-methyl-2'-oxo-1',2'-dihydrospiro[cyclopropane-1,3'-indole]-2-carbonitrile (895576-37-1,895576-36-0)

Guidance literature:

With potassium carbonate; In dimethyl sulfoxide; at 20 ℃; for 4h;

DOI:10.1016/j.tet.2007.05.009

upstream raw materials:

(1-methyl-2-oxo-2,3-dihydro-1H-indol-3-yl)acetonitrile

1,1-dibromomethane

3-diazo-1-methyl-1,3-dihydro-indol-2-one

acrylonitrile

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 895576-37-1 (1S,2R)-2'-OXOSPIRO[CYCLOPROPANE-1,3'-INDOLINE]-2-CARBONITRILE

Send

Send

Metric Ton KG G Pound L ML

Send

Send