4-(4-FLUOROPHENYL)-4-OXOBUTANENITRILE

Base Information

• Chemical Name: 4-(4-FLUOROPHENYL)-4-OXOBUTANENITRILE
• CAS No.: 756489-25-5
• Molecular Formula: C₁₀H₈FNO
• Molecular Weight: 177.178
• Hs Code.: 2926909090
• Mol file: 756489-25-5.mol

Synonyms:4-(4-FLUOROPHENYL)-4-OXOBUTANENITRILE;4-(4-FLUOROPHENYL)-4-OXOBUTYRONITRILE;SALOR-INT L481998-1EA

Chemical Property of 4-(4-FLUOROPHENYL)-4-OXOBUTANENITRILE

Chemical Property:

• Vapor Pressure: 8.7E-05mmHg at 25°C
• Boiling Point: 340.3°C at 760 mmHg
• Flash Point: 159.6°C
• PSA: 40.86000
• Density: 1.168g/cm³
• LogP: 2.31218

Purity/Quality:

99%+ ^*data from raw suppliers

4-(4-Fluorophenyl)-4-oxobutanenitrile ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(4-FLUOROPHENYL)-4-OXOBUTANENITRILE

There total 11 articles about 4-(4-FLUOROPHENYL)-4-OXOBUTANENITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

4-fluorobenzaldehyde (459-57-4) + acrylonitrile (107-13-1,25014-41-9) → 4-(4-fluoro-phenyl)-4-oxo-butyronitrile (756489-25-5)

Guidance literature:

With Cu doped graphitic carbon nitride; In water; at 20 ℃; for 8h; Sealed tube; Irradiation; Green chemistry;

DOI:10.1002/ejoc.202000945

Reference yield: 79.0%

1-(4-fluorophenyl)cyclopropan-1-ol + 3-oxo-1λ3-benzo[d][1,2]iodaoxole-1(3H)-carbonitrile (172876-96-9) → 4-(4-fluoro-phenyl)-4-oxo-butyronitrile (756489-25-5)

Guidance literature:

With copper(l) iodide; In 1,2-dichloro-ethane; at 20 ℃; for 12h; Schlenk technique; Inert atmosphere;

DOI:10.1039/c7ob00627f

Reference yield: 73.0%

4-fluorobenzoyl chloride (403-43-0) + acrylonitrile (107-13-1,25014-41-9) → 4-(4-fluoro-phenyl)-4-oxo-butyronitrile (756489-25-5)

Guidance literature:

With samarium; In N,N-dimethyl-formamide; at 20 ℃; for 1.5h;

upstream raw materials:

4-fluorobenzoyl chloride

acrylonitrile

4-fluorobenzaldehyde

para-fluorostyrene