2-Chloro-4-ethoxybenzaldehyde

Base Information

• Chemical Name: 2-Chloro-4-ethoxybenzaldehyde
• CAS No.: 245368-31-4
• Molecular Weight: 184.62
• Hs Code.: 2914500090
• European Community (EC) Number: 842-291-4
• Mol file: 245368-31-4.mol

Synonyms:2-chloro-4-ethoxybenzaldehyde;245368-31-4;SCHEMBL6319246;GJOPPYKPFJLRNE-UHFFFAOYSA-N;VJA36831;MFCD23132246;AKOS022958761;DA-26577;LS-13600;CS-0195382;E92595;EN300-1232555;Z1511766843

Chemical Property of 2-Chloro-4-ethoxybenzaldehyde

Chemical Property:

• XLogP3: 2.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 184.0291072
• Heavy Atom Count: 12
• Complexity: 150

Purity/Quality:

99% ^*data from raw suppliers

2-Chloro-4-ethoxybenzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CCOC1=CC(=C(C=C1)C=O)Cl

Technology Process of 2-Chloro-4-ethoxybenzaldehyde

There total 2 articles about 2-Chloro-4-ethoxybenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2-chloro-4-hydroxybenzaldehyde (56962-11-9) + ethyl iodide (75-03-6) → 4-ethoxy-2-chloro-benzaldehyde (245368-31-4)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 2.5h;

Reference yield:

hydrogen cyanide (74-90-8) + 1-chloro-3-ethoxybenzene (2655-83-6) → 4-ethoxy-2-chloro-benzaldehyde (245368-31-4)

Guidance literature:

With hydrogenchloride; aluminium trichloride; benzene; at 25 ℃;

Reference yield:

4-ethoxy-2-chloro-benzaldehyde (245368-31-4) → C19H20ClFN2O3

Guidance literature:

Multi-step reaction with 2 steps

1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 18 h / 20 °C

1.2: 1 h / 20 °C

2.1: dimethylaminoacetic acid; caesium carbonate; copper(l) iodide / 1,4-dioxane / 1 h / 150 °C / Microwave irradiation

With copper(l) iodide; dimethylaminoacetic acid; caesium carbonate; 3-chloro-benzenecarboperoxoic acid; In 1,4-dioxane; dichloromethane;

upstream raw materials:

hydrogen cyanide

1-chloro-3-ethoxybenzene

2-chloro-4-hydroxybenzaldehyde

ethyl iodide

Refernces