4-[(dimethylamino)sulfonyl]-1-Piperidinecarboxylic acid phenylmethyl ester

Base Information

• Chemical Name: 4-[(dimethylamino)sulfonyl]-1-Piperidinecarboxylic acid phenylmethyl ester
• CAS No.: 1083326-06-0
• Molecular Formula: C₁₅H₂₂N₂O₄S
• Molecular Weight: 326.417
• Mol file: 1083326-06-0.mol

Synonyms:4-[(dimethylamino)sulfonyl]-1-Piperidinecarboxylic acid phenylmethyl ester

Chemical Property of 4-[(dimethylamino)sulfonyl]-1-Piperidinecarboxylic acid phenylmethyl ester

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-[(dimethylamino)sulfonyl]-1-Piperidinecarboxylic acid phenylmethyl ester

There total 1 articles about 4-[(dimethylamino)sulfonyl]-1-Piperidinecarboxylic acid phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

4-(chlorosulfonyl)piperidine-1-carboxylic acid benzyl ester (287953-54-2) + dimethyl amine (124-40-3) → benzyl 4-[(dimethylamino)sulfonyl]-1-piperidinecarboxylate (1083326-06-0)

Guidance literature:

In tetrahydrofuran; water; at 20 ℃; for 2h;

Reference yield: 87.0%

benzyl 4-[(dimethylamino)sulfonyl]-1-piperidinecarboxylate (1083326-06-0) → N,N-dimethyl-4-piperidinesulfonamide (956075-49-3)

Guidance literature:

With hydrogen; palladium on activated carbon; In methanol; at 20 ℃; for 1h;

Reference yield:

benzyl 4-[(dimethylamino)sulfonyl]-1-piperidinecarboxylate (1083326-06-0) → C14H18BrF3N2O2S

Guidance literature:

Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; methanol / 2 h / 20 °C / 760.05 Torr

2: potassium carbonate; 1,3-dimethyl-2-imidazolidinone / 5 h / 190 °C / Inert atmosphere

With 1,3-dimethyl-2-imidazolidinone; palladium 10% on activated carbon; hydrogen; potassium carbonate; In tetrahydrofuran; methanol;

upstream raw materials:

4-(chlorosulfonyl)piperidine-1-carboxylic acid benzyl ester

dimethyl amine

Downstream raw materials:

N,N-dimethyl-4-piperidinesulfonamide