4,6-Dichloro-2-(4-methoxyphenyl)pyrimidine

Base Information

Chemical Name:4,6-Dichloro-2-(4-methoxyphenyl)pyrimidine
CAS No.:83217-08-7
Molecular Formula:C11H8Cl2N2O
Molecular Weight:255.103
Hs Code.:2933599090
DSSTox Substance ID:DTXSID50477526
Nikkaji Number:J1.902.727I
Wikidata:Q82310287
Mol file:83217-08-7.mol

Synonyms:4,6-DICHLORO-2-(4-METHOXYPHENYL)PYRIMIDINE;83217-08-7;4,6-dichloro-2-(4-methoxyphenyl)-pyrimidine;AGN-PC-0NHS5W;SCHEMBL7377873;DTXSID50477526;CHLAKIWCDADMAD-UHFFFAOYSA-N;AKOS012921606;2p-methoxyphenyl-4,6-dichloropyrimidine

Suppliers and Price of 4,6-Dichloro-2-(4-methoxyphenyl)pyrimidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
4,6-DICHLORO-2-(4-METHOXYPHENYL)PYRIMIDINE 95.00%
5MG
$ 499.32

Total 7 raw suppliers

Chemical Property of 4,6-Dichloro-2-(4-methoxyphenyl)pyrimidine

Chemical Property:

PSA：35.01000
LogP:3.45900
XLogP3:4.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:254.0013683
Heavy Atom Count:16
Complexity:212

Purity/Quality:

98%+ ^*data from raw suppliers

4,6-DICHLORO-2-(4-METHOXYPHENYL)PYRIMIDINE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=C(C=C1)C2=NC(=CC(=N2)Cl)Cl

Technology Process of 4,6-Dichloro-2-(4-methoxyphenyl)pyrimidine

There total 7 articles about 4,6-Dichloro-2-(4-methoxyphenyl)pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 15726-40-6
2-(4-methoxyphenyl)-4,6-dihydroxypyrimidine

: 83217-08-7
4,6-dichloro-2-(4-methoxyphenyl)-pyrimidine

Guidance literature:: With trichlorophosphate; at 110 ℃; for 5h;
DOI:10.1016/j.ejmech.2018.03.018

Reference yield: 57.0%

: Vilsmeier-Haack reagent

: 15726-40-6
2-(4-methoxyphenyl)-4,6-dihydroxypyrimidine

: 948863-46-5
4,6-dichloro-2-(p-methoxyphenyl)pyrimidine-5-carbaldehyde

: 83217-08-7
4,6-dichloro-2-(4-methoxyphenyl)-pyrimidine

Guidance literature:: at 20 - 100 ℃; for 5.5h;
DOI:10.1021/ol071226a

Reference yield:

: 123-11-5
4-methoxy-benzaldehyde

: 83217-08-7
4,6-dichloro-2-(4-methoxyphenyl)-pyrimidine

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydroxylamine hydrochloride / dimethyl sulfoxide / 0.5 h / 100 °C

2.1: sodium methylate / methanol / 48 h / 20 °C

2.2: 24 h / 20 °C

3.1: sodium methylate; methanol / 4 h / Reflux

4.1: trichlorophosphate / 5 h / 110 °C

With methanol; hydroxylamine hydrochloride; sodium methylate; trichlorophosphate; In methanol; dimethyl sulfoxide;
DOI:10.1016/j.ejmech.2018.03.018