15726-40-6Relevant academic research and scientific papers
Structure-activity relationships of 2, 4-disubstituted pyrimidines as dual ERα/VEGFR-2 ligands with anti-breast cancer activity
Luo, Guoshun,Tang, Zhichao,Lao, Kejing,Li, Xinyu,You, Qidong,Xiang, Hua
, p. 783 - 795 (2018)
Both ERα and VEGFR-2 are important targets for cancer therapies. Here a series of 2, 4-disubstituted pyrimidine derivatives were designed, synthesized and evaluated as dual ERα/VEGFR-2 ligands. Most of the derivatives exhibited potent activities in both e
Aryl and heterocyclyl substituted pyrimidine derivatives as anti-coagulants
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Example Pr1, (2008/06/13)
This invention is directed to aryl and heterocyclyl substituted pyrimidine derivatives selected from the following formulae: wherein Z1, Z2, R1, R2, R3, R4, R5and R6are defined herein. These compounds are useful as anti-coagulants.
Aryl and heterocyclyl substituted pyrimidine derivatives as anti-coagulants
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, (2008/06/13)
This invention is directed to aryl and heterocyclyl substituted pyrimidine derivatives selected from the following formulae: wherein Z1, Z2, R1, R2, R3, R4, R5 and R6 are defined herein. These compounds are useful as anti-coagulants.
Phenylpyrimidines as antidotes for protecting cultivated plants against phytotoxic damage caused by herbicides
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, (2008/06/13)
Phenylpyrimidines of the formula I as defined below are suitable as antidotes for protecting cultivated plants from phytotoxic effects caused by herbicides. These antidotes, either together with the herbicides or also by themselves, are applied to the pla
