1-Piperidinecarboxylic acid, 4-(3-ethoxy-3-oxo-1-propyn-1-yl)-4-hydroxy-, 1,1-diMethylethyl ester

Base Information

Chemical Name:1-Piperidinecarboxylic acid, 4-(3-ethoxy-3-oxo-1-propyn-1-yl)-4-hydroxy-, 1,1-diMethylethyl ester
CAS No.:374794-90-8
Molecular Formula:C₁₅H₂₃NO₅
Molecular Weight:297.351
Hs Code.:
Mol file:374794-90-8.mol

Synonyms:1-Piperidinecarboxylic acid, 4-(3-ethoxy-3-oxo-1-propyn-1-yl)-4-hydroxy-, 1,1-diMethylethyl ester

Suppliers and Price of 1-Piperidinecarboxylic acid, 4-(3-ethoxy-3-oxo-1-propyn-1-yl)-4-hydroxy-, 1,1-diMethylethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

ChemScene
1-Piperidinecarboxylicacid,4-(3-ethoxy-3-oxo-1-propyn-1-yl)-4-hydroxy-,1,1-dimethylethylester
250mg
$ 145.00

AK Scientific
1-Piperidinecarboxylicacid,4-(3-ethoxy-3-oxo-1-propyn-1-yl)-4-hydroxy-,1,1-dimethylethylester
1g
$ 802.00

Total 7 raw suppliers

Chemical Property of 1-Piperidinecarboxylic acid, 4-(3-ethoxy-3-oxo-1-propyn-1-yl)-4-hydroxy-, 1,1-diMethylethyl ester

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Boiling Point:426.804°C at 760 mmHg
Flash Point:211.924°C
PSA：76.07000
Density:1.182g/cm³
LogP:1.25280

Purity/Quality:

≥95% ^*data from raw suppliers

1-Piperidinecarboxylicacid,4-(3-ethoxy-3-oxo-1-propyn-1-yl)-4-hydroxy-,1,1-dimethylethylester ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1-Piperidinecarboxylic acid, 4-(3-ethoxy-3-oxo-1-propyn-1-yl)-4-hydroxy-, 1,1-diMethylethyl ester

There total 1 articles about 1-Piperidinecarboxylic acid, 4-(3-ethoxy-3-oxo-1-propyn-1-yl)-4-hydroxy-, 1,1-diMethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 623-47-2
propynoic acid ethyl ester

: 374794-90-8
1,1-dimethylethyl 4-(3-ethoxy-3-oxo-1-propynyl)-4-hydroxy-1-piperidinecarboxylate

Guidance literature:: propynoic acid ethyl ester; With n-butyllithium; In tetrahydrofuran; at -78 ℃;

N-tert-butyloxycarbonylpiperidin-4-one; In tetrahydrofuran; at -78 ℃; for 1h;
DOI:10.1016/S0960-894X(02)00250-0

Reference yield:

: 374794-90-8
1,1-dimethylethyl 4-(3-ethoxy-3-oxo-1-propynyl)-4-hydroxy-1-piperidinecarboxylate

: 2-(3,5-bis-trifluoromethyl-phenyl)-N-[4-(1-oxa-8-aza-spiro[4.5]dec-8-yl)-1-phenyl-cyclohexyl]-propionamide

Guidance literature:: Multi-step reaction with 6 steps

1: H₂ / Pd/C / ethanol

2: p-TsOH / toluene / 3 h / Heating

3: DIBAL-H / CH₂Cl₂ / 5 h / -78 - 0 °C

4: PPh₃; diethyl azodicarboxylate / tetrahydrofuran / 16 h / 0 - 20 °C

5: AcCl; MeOH / 16 h / 0 - 20 °C

6: NaCNBH₃; ZnCl₂ / methanol / 16 h / 20 °C

With methanol; hydrogen; diisobutylaluminium hydride; sodium cyanoborohydride; toluene-4-sulfonic acid; acetyl chloride; triphenylphosphine; zinc(II) chloride; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; toluene; 4: Mitsunobu reaction;
DOI:10.1016/S0960-894X(02)00250-0

Reference yield:

: 374794-90-8
1,1-dimethylethyl 4-(3-ethoxy-3-oxo-1-propynyl)-4-hydroxy-1-piperidinecarboxylate

: 2-(3,5-bis-trifluoromethyl-phenyl)-N-[4-(1-oxa-8-aza-spiro[4.5]dec-8-yl)-1-phenyl-cyclohexyl]-propionamide

Guidance literature:: Multi-step reaction with 6 steps

1: H₂ / Pd/C / ethanol

2: p-TsOH / toluene / 3 h / Heating

3: DIBAL-H / CH₂Cl₂ / 5 h / -78 - 0 °C

4: PPh₃; diethyl azodicarboxylate / tetrahydrofuran / 16 h / 0 - 20 °C

5: AcCl; MeOH / 16 h / 0 - 20 °C

6: NaCNBH₃; ZnCl₂ / methanol / 16 h / 20 °C

With methanol; hydrogen; diisobutylaluminium hydride; sodium cyanoborohydride; toluene-4-sulfonic acid; acetyl chloride; triphenylphosphine; zinc(II) chloride; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; toluene; 4: Mitsunobu reaction;
DOI:10.1016/S0960-894X(02)00250-0