tert-butyl 4-(3-ethoxy-3-oxopropyl)-4-hydroxypiperidine-1-carboxylate

Base Information

• Chemical Name: tert-butyl 4-(3-ethoxy-3-oxopropyl)-4-hydroxypiperidine-1-carboxylate
• CAS No.: 374794-91-9
• Molecular Formula: C₁₅H₂₇NO₅
• Molecular Weight: 301.383
• Mol file: 374794-91-9.mol

Synonyms:4-Piperidinepropanoic acid, 1-[(1,1-diMethylethoxy)carbonyl]-4-hydroxy-, ethyl ester

Chemical Property of tert-butyl 4-(3-ethoxy-3-oxopropyl)-4-hydroxypiperidine-1-carboxylate

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 390.238°C at 760 mmHg
• Flash Point: 189.809°C
• Density: 1.113g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-butyl 4-(3-ethoxy-3-oxopropyl)-4-hydroxypiperidine-1-carboxylate

There total 3 articles about tert-butyl 4-(3-ethoxy-3-oxopropyl)-4-hydroxypiperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,1-dimethylethyl 4-(3-ethoxy-3-oxo-1-propynyl)-4-hydroxy-1-piperidinecarboxylate (374794-90-8) → 1,1-dimethylethyl 4-(3-ethoxy-3-oxoprop-1-yl)-4-hydroxy-1-piperidinecarboxylate (374794-91-9)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol;

DOI:10.1016/S0960-894X(02)00250-0

Reference yield:

N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) → 1,1-dimethylethyl 4-(3-ethoxy-3-oxoprop-1-yl)-4-hydroxy-1-piperidinecarboxylate (374794-91-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-BuLi / tetrahydrofuran / -78 °C

1.2: tetrahydrofuran / 1 h / -78 °C

2.1: H₂ / Pd/C / ethanol

With n-butyllithium; hydrogen; palladium on activated charcoal; In tetrahydrofuran; ethanol;

DOI:10.1016/S0960-894X(02)00250-0

Reference yield:

propynoic acid ethyl ester (623-47-2) → 1,1-dimethylethyl 4-(3-ethoxy-3-oxoprop-1-yl)-4-hydroxy-1-piperidinecarboxylate (374794-91-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-BuLi / tetrahydrofuran / -78 °C

1.2: tetrahydrofuran / 1 h / -78 °C

2.1: H₂ / Pd/C / ethanol

With n-butyllithium; hydrogen; palladium on activated charcoal; In tetrahydrofuran; ethanol;

DOI:10.1016/S0960-894X(02)00250-0

upstream raw materials:

1,1-dimethylethyl 4-(3-ethoxy-3-oxo-1-propynyl)-4-hydroxy-1-piperidinecarboxylate

N-tert-butyloxycarbonylpiperidin-4-one

propynoic acid ethyl ester

Downstream raw materials:

tert-butyl 4-hydroxy-4-(3-hydroxypropyl)piperidine-1-carboxylate

1,1-dimethylethyl 1-oxa-8-azaspiro[4,5]decane-8-carboxylate

1-oxa-8-aza-spiro[4.5]decan-2-one

4-dioxa-8-azaspiro[4.5]decane