6-chloro-4-forMyl-N,N-diisopropylnicotinaMide

Base Information

Chemical Name:6-chloro-4-forMyl-N,N-diisopropylnicotinaMide
CAS No.:905273-88-3
Molecular Formula:C₁₃H₁₇ClN₂O₂
Molecular Weight:268.743
Hs Code.:
Mol file:905273-88-3.mol

Synonyms:6-chloro-4-forMyl-N,N-diisopropylnicotinaMide;6-chloro-4-formyl-N,N-diisopropylpyridine-3-carboxamide

Suppliers and Price of 6-chloro-4-forMyl-N,N-diisopropylnicotinaMide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 1 raw suppliers

Chemical Property of 6-chloro-4-forMyl-N,N-diisopropylnicotinaMide

Chemical Property:

Boiling Point:431.2±45.0 °C(Predicted)
PKA:-2.80±0.10(Predicted)
PSA：50.27000
Density:1.176±0.06 g/cm3(Predicted)
LogP:2.80650

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 6-chloro-4-forMyl-N,N-diisopropylnicotinaMide

There total 5 articles about 6-chloro-4-forMyl-N,N-diisopropylnicotinaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.8%

: 905273-87-2
6-chloro-N,N-bis(propan-2-yl)pyridine-3-carboxamide

: 68-12-2,33513-42-7
N,N-dimethyl-formamide

: 905273-88-3
6-chloro-4-formyl-N,N-bis(propan-2-yl)pyridine-3-carboxamide

Guidance literature:: 6-chloro-N,N-bis(propan-2-yl)pyridine-3-carboxamide; With n-butyllithium; diisopropylamine; In diethyl ether; at -78 ℃; for 0.25h;

N,N-dimethyl-formamide; In diethyl ether; at -78 ℃; for 1h;

Reference yield: 65.0%

: 905273-87-2
6-chloro-N,N-bis(propan-2-yl)pyridine-3-carboxamide

: 109-94-4
formic acid ethyl ester

: 905273-88-3
6-chloro-4-formyl-N,N-bis(propan-2-yl)pyridine-3-carboxamide

Guidance literature:: With lithium diisopropyl amide; In diethyl ether; at -75 ℃; for 1h;
DOI:10.1016/j.bmcl.2013.06.090

Reference yield:

: 58757-38-3
6-Chloronicotinoyl chloride

: 905273-88-3
6-chloro-4-formyl-N,N-bis(propan-2-yl)pyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 10 °C

2: lithium diisopropyl amide / diethyl ether / 1 h / -75 °C

With N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; In diethyl ether; dichloromethane;
DOI:10.1016/j.bmcl.2013.06.090