2-Hydroxy-5-methylpyridine

Base Information

• Chemical Name: 2-Hydroxy-5-methylpyridine
• CAS No.: 91914-06-6
• Molecular Formula: C₆H₇NO
• Molecular Weight: 109.128
• Hs Code.: 29333995
• European Community (EC) Number: 213-713-9,618-801-4
• UNII: C173P2D70Y
• DSSTox Substance ID: DTXSID20143120
• Nikkaji Number: J110.369E
• Wikidata: Q27275047
• Mol file: 91914-06-6.mol

Synonyms:5-methyl-2-pyridone

Chemical Property of 2-Hydroxy-5-methylpyridine

Chemical Property:

• Appearance/Colour: light yellow crystalline powder
• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 183-187 °C(lit.)
• Refractive Index: 1.551
• Boiling Point: 304.2 °C at 760 mmHg
• PKA: 10.19±0.10(Predicted)
• Flash Point: 170.6 °C
• PSA: 33.12000
• Density: 1.053 g/cm³
• LogP: 1.09560
• Storage Temp.: Inert atmosphere,Room Temperature
• XLogP3: 0.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 109.052763847
• Heavy Atom Count: 8
• Complexity: 167

Purity/Quality:

97% ^*data from raw suppliers

2-Hydroxy-5-methylpyridine 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn,Xi
• Statements: 22-37/38-41-40-36/37/38
• Safety Statements: 26-36-22

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CNC(=O)C=C1

Technology Process of 2-Hydroxy-5-methylpyridine

There total 12 articles about 2-Hydroxy-5-methylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

(5-methyl-pyridin-2-yl)amine (1603-41-4) → 5-methyl-pyridin-2-ol (1003-68-5,91914-06-6)

Guidance literature:

(5-methyl-pyridin-2-yl)amine; With sulfuric acid; water; sodium nitrite; at 20 ℃; for 6h; Heating / reflux;

With sodium carbonate; In water; at 0 ℃; pH=8;

Reference yield: 71.0%

(5-methyl-pyridin-2-yl)amine (1603-41-4) → 5-methyl-pyridin-2-ol (1003-68-5,91914-06-6) + 3-methylpyridin-2-ol (1003-56-1,91914-04-4)

Guidance literature:

Reference yield:

methyl aminal ester + Methyl (E)-2-pentenoate (15790-87-1,818-59-7,15790-88-2) → 5-methyl-pyridin-2-ol (1003-68-5,91914-06-6)

Guidance literature:

With ammonia; sodium methylate; In methanol; water;

upstream raw materials:

(5-methyl-pyridin-2-yl)amine

6-hydroxy-3-methylpicolinic acid

2-fluoro-5-methylpyridine

hydrogenchloride

Downstream raw materials:

(5-methyl-pyridin-2-yloxy)-acetic acid ethyl ester

2-mercapto-5-methylpyridine

5-(((5-methylpyridin-2-yl)oxy)methyl)-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridine

2-hydroxy-5-methyl-3-nitropyridine