4-Chloro-3,5-diMethylbenzoic acid Methyl ester

Base Information

• Chemical Name: 4-Chloro-3,5-diMethylbenzoic acid Methyl ester
• CAS No.: 1192547-87-7
• Molecular Formula: C10H11ClO2
• Molecular Weight: 198.64614
• Hs Code.: 2916399090
• Mol file: 1192547-87-7.mol

Synonyms:4-Chloro-3,5-diMethylbenzoic acid Methyl ester;Methyl 4-chloro-3,5-diMethylbenzoate

Chemical Property of 4-Chloro-3,5-diMethylbenzoic acid Methyl ester

Chemical Property:

• PSA: 26.30000
• LogP: 2.74340

Purity/Quality:

97% ^*data from raw suppliers

Methyl4-Chloro-3,5-dimethylbenzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Chloro-3,5-diMethylbenzoic acid Methyl ester

There total 2 articles about 4-Chloro-3,5-diMethylbenzoic acid Methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanol (67-56-1) + 4-chloro-3,5-dimethylbenzenecarboxylic acid (90649-78-8) → 4-chloro-3,5-dimethylbenzoic acid methyl ester (1192547-87-7)

Guidance literature:

With hydrogenchloride; In water; for 16h; Reflux;

Reference yield:

carbon dioxide (124-38-9,18923-20-1) + 2,6-dimethyl-1-chlorobenzene (6781-98-2) + diazomethyl-trimethyl-silane (18107-18-1) → 4-chloro-3,5-dimethylbenzoic acid methyl ester (1192547-87-7) + methyl 3-chloro-2,4-dimethylbenzenecarboxylate

Guidance literature:

carbon dioxide; 2,6-dimethyl-1-chlorobenzene; With [1,2-bis(dicyclohexylphosphino)ethane]rhodium(I) chloride dimer; Al⁽³⁺⁾*1.5CH₃^(1-)*1.5C₂H₅O^(1-); tetramethylurea; In N,N-dimethyl acetamide; at 20 - 145 ℃; for 6h; under 760.051 Torr; Inert atmosphere;

With hydrogenchloride; In diethyl ether; N,N-dimethyl acetamide; water; Inert atmosphere;

diazomethyl-trimethyl-silane; In methanol; diethyl ether; at 0 ℃; regioselective reaction; Catalytic behavior; Inert atmosphere;

DOI:10.1039/c4cc06188h

Reference yield:

4-chloro-3,5-dimethylbenzoic acid methyl ester (1192547-87-7) + (1S,2S)-2-{5-[(R)-7-fluoro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-indan-1-ylamino]-pyridin-2-yl}-cyclopropanecarboxylic acid methyl ester → C27H25FN2O4

Guidance literature:

4-chloro-3,5-dimethylbenzoic acid methyl ester; (1S,2S)-2-{5-[(R)-7-fluoro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-indan-1-ylamino]-pyridin-2-yl}-cyclopropanecarboxylic acid methyl ester; With potassium phosphate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); In 1,4-dioxane; water; at 80 ℃; Inert atmosphere;

With trifluoroacetic acid; at 20 ℃;

upstream raw materials:

methanol

4-chloro-3,5-dimethylbenzenecarboxylic acid

carbon dioxide

2,6-dimethyl-1-chlorobenzene

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