Pazinaclone

Base Information

• Chemical Name: Pazinaclone
• CAS No.: 151764-87-3
• Molecular Formula: C25H23CIN4O4
• Molecular Weight: 0
• Mol file: 151764-87-3.mol

Synonyms:

Chemical Property of Pazinaclone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Pazinaclone

There total 10 articles about Pazinaclone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2,7-dichloro-1,8-naphthyridine (55243-02-2) + 3-(2-oxo-2-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)ethyl)isoindolin-1-one → 2-(7-chloro-1,8-naphthyridin-2-yl)-3-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)carbonylmethylisoindolin-1-one (103255-66-9,147724-30-9,151764-87-3)

Guidance literature:

With palladium diacetate; potassium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 80 ℃; Schlenk technique; Inert atmosphere;

DOI:10.1002/chem.201600107

Reference yield: 68.0%

N-(7-chloro-1,8-naphthyridin-2-yl)benzamide (104917-09-1) + 1-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)propenone (79404-70-9) → 2-(7-chloro-1,8-naphthyridin-2-yl)-3-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)carbonylmethylisoindolin-1-one (103255-66-9,147724-30-9,151764-87-3)

Guidance literature:

With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; copper diacetate; In acetonitrile; at 80 ℃; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.orglett.8b04026

Reference yield: 64.0%

carbon monoxide (201230-82-2) + 2-chloro-7-amino-1,8-naphthyridine (15944-33-9) + 8-[(2E)-3-(2-iodophenyl)prop-2-enoyl]-1,4-dioxa-8-azaspiro[4.5]decane → 2-(7-chloro-1,8-naphthyridin-2-yl)-3-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)carbonylmethylisoindolin-1-one (103255-66-9,147724-30-9,151764-87-3)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; trifuran-2-yl-phosphane; caesium carbonate; In 1,4-dioxane; at 110 ℃; under 760 Torr;

DOI:10.1016/j.tetlet.2003.08.036

upstream raw materials:

carbon monoxide

2-chloro-7-amino-1,8-naphthyridine

3-oxo-2-(7-chloro-1,8-naphthyridin-2-yl)isoindoline-1-acetic acid

diethyl cyanophosphonate

Refernces

• 1、 Zhang, Yan,Zhu, Haiqian,Huang, Yuting,Hu, Qi,He, Yu,Wen, Yihang,Zhu, Gangguo. "Multicomponent Synthesis of Isoindolinones by RhIII Relay Catalysis: Synthesis of Pagoclone and Pazinaclone from Benzaldehyde". supporting information. p. 1273 - 1277. Retrieved 2019/02/26.
• 2、 Gaj, Xinjie,Grigg, Ronald,Khamnaen, Tossapol,Rajviroongit, Shuleewan,Sridharan, Visuvanathar,Zhang, Lixin,Collard, Simon,Keep, Ann. "Synthesis of 3-substituted isoindolin-1-ones via a palladium-catalysed 3-component carbonylation/amination/Michael addition process". . p. 7441 - 7444. Retrieved 2007/10/03.