(S)-Methyl morpholine-3-carboxylate hydrochloride

Base Information

• Chemical Name: (S)-Methyl morpholine-3-carboxylate hydrochloride
• CAS No.: 1447972-26-0
• Molecular Formula: C₆H₁₁NO₃*ClH
• Molecular Weight: 181.619
• Hs Code.: 2934999090
• Mol file: 1447972-26-0.mol

Synonyms:3-Morpholinecarboxylic acid, methyl ester, hydrochloride (1:1), (3S)-;

Chemical Property of (S)-Methyl morpholine-3-carboxylate hydrochloride

Chemical Property:

• PSA: 47.56000
• LogP: 0.27860
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98% ^*data from raw suppliers

(S)-Methylmorpholine-3-carboxylatehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-Methyl morpholine-3-carboxylate hydrochloride

There total 3 articles about (S)-Methyl morpholine-3-carboxylate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-(tert-butoxycarbonyl)morpholine-3-carboxylic acid (212650-43-6) + methanol (67-56-1) → 3-morpholinecarboxylic acid methyl ester hydrochloride (1447972-26-0)

Guidance literature:

With thionyl chloride; at 0 - 80 ℃; for 24h;

Reference yield:

(S)-4-tert-butyl 3-methyl morpholine-3,4-dicarboxylate (215917-98-9,885321-46-0) → methyl (3S)-morpholine-3-carboxylate hydrochloride (1447972-26-0)

Guidance literature:

With hydrogenchloride; In dichloromethane; water; at 20 ℃; for 3h;

Reference yield:

(S)-4-[(tert-butoxy)carbonyl]morpholine-3-carboxylic acid (783350-37-8) → methyl (3S)-morpholine-3-carboxylate hydrochloride (1447972-26-0)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol; diethyl ether; benzene

2: hydrogenchloride / dichloromethane; water / 3 h / 20 °C

With hydrogenchloride; In methanol; diethyl ether; dichloromethane; water; benzene;

upstream raw materials:

4-(tert-butoxycarbonyl)morpholine-3-carboxylic acid

methanol

(S)-4-tert-butyl 3-methyl morpholine-3,4-dicarboxylate

(S)-4-[(tert-butoxy)carbonyl]morpholine-3-carboxylic acid

Refernces

• 1、 -. "COMBINATIONS OF HEPATITIS C VIRUS INHIBITORS". Page/Page column 595. . Retrieved 2015/02/02.