4-amino-2,6-dichlorobenzoic acid

Base Information

• Chemical Name: 4-amino-2,6-dichlorobenzoic acid
• CAS No.: 5204-46-6
• Molecular Formula: C7H5Cl2NO2
• Molecular Weight: 206.028
• Hs Code.: 2922499990
• Mol file: 5204-46-6.mol

Synonyms:4-amino-2,6-dichlorobenzoic acid;2,6-Dichloro-4-aminobenzoic acid

Chemical Property of 4-amino-2,6-dichlorobenzoic acid

Chemical Property:

• PSA: 63.32000
• LogP: 2.85500

Purity/Quality:

99% ^*data from raw suppliers

4-Amino-2,6-dichlorobenzoicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-amino-2,6-dichlorobenzoic acid

There total 3 articles about 4-amino-2,6-dichlorobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,3-dichloro-2-methyl-5-nitrobenzene (7149-69-1) → 4-amino-2,6-dichlorobenzoic acid (5204-46-6)

Guidance literature:

Multi-step reaction with 2 steps

1: KMnO₄; aqueous pyridine

2: palladium/charcoal; methanol; N₂H₄+H₂O

With pyridine; methanol; potassium permanganate; palladium on activated charcoal; hydrazine hydrate;

DOI:10.1021/ja01644a037

Reference yield:

methyl 4-amino-2,6-dichlorobenzoate (232275-49-9) → 4-amino-2,6-dichlorobenzoic acid (5204-46-6)

Guidance literature:

With lithium hydroxide monohydrate; water; In tetrahydrofuran; methanol; at 65 ℃; for 48h;

Reference yield:

2,6-dichloro-4-nitrobenzoic acid (22509-50-8) → 4-amino-2,6-dichlorobenzoic acid (5204-46-6)

Guidance literature:

With methanol; palladium on activated charcoal; hydrazine hydrate;

DOI:10.1021/ja01644a037

upstream raw materials:

2,6-dichloro-4-nitrobenzoic acid

1,3-dichloro-2-methyl-5-nitrobenzene

methyl 4-amino-2,6-dichlorobenzoate

Refernces