1-[(2'-Cyano[1,1'-biphenyl]-4-yl)MethylaMino]-N-pentanoylcyclopentanecarboxaMide

Base Information

• Chemical Name: 1-[(2'-Cyano[1,1'-biphenyl]-4-yl)MethylaMino]-N-pentanoylcyclopentanecarboxaMide
• CAS No.: 141745-71-3
• Molecular Formula: C25H29N3O2
• Molecular Weight: 403.524
• Mol file: 141745-71-3.mol

Synonyms:1-[(2'-Cyano[1,1'-biphenyl]-4-yl)MethylaMino]-N-pentanoylcyclopentanecarboxaMide;N-[(2'-Cyano[1,1'-biphenyl]-4-yl)Methyl]-1-[(1-oxopentyl)aMino]cyclopentanecarboxaMide

Chemical Property of 1-[(2'-Cyano[1,1'-biphenyl]-4-yl)MethylaMino]-N-pentanoylcyclopentanecarboxaMide

Chemical Property:

• PSA: 88.97000
• LogP: 6.14128

Purity/Quality:

> 95% ^*data from raw suppliers

N-[(2''-Cyano[1,1''-biphenyl]-4-yl)methyl]-1-[(1-oxopentyl)amino]cyclopentanecarboxamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: An impurity of Irbesartan (I751000).

Technology Process of 1-[(2'-Cyano[1,1'-biphenyl]-4-yl)MethylaMino]-N-pentanoylcyclopentanecarboxaMide

There total 8 articles about 1-[(2'-Cyano[1,1'-biphenyl]-4-yl)MethylaMino]-N-pentanoylcyclopentanecarboxaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

N-pentanoylaminocyclopentane-1-carboxylic acid (15026-80-9) + [(2'-cyanobiphenyl-4-yl)methyl]amine (133690-92-3) → 1-pentanoylamino-cyclopentanecarboxylic acid (2'-cyano-biphenyl-4-ylmethyl)-amide (141745-71-3)

Guidance literature:

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane; at 25 - 35 ℃;

DOI:10.1515/HC.2006.12.5.323

Reference yield: 93.0%

2-(4'-aminomethylphenyl)benzonitrile hydrogen chloride + N-pentanoylaminocyclopentane-1-carboxylic acid (15026-80-9) → 1-pentanoylamino-cyclopentanecarboxylic acid (2'-cyano-biphenyl-4-ylmethyl)-amide (141745-71-3)

Guidance literature:

With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In dichloromethane; at 38 - 41 ℃; for 7h;

DOI:10.1080/00397910701471279

Reference yield: 82.0%

1-(pentanoylamino)cyclopentanecarboxamide (177219-40-8) + 4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile (114772-54-2) → 1-pentanoylamino-cyclopentanecarboxylic acid (2'-cyano-biphenyl-4-ylmethyl)-amide (141745-71-3)

Guidance literature:

1-(pentanoylamino)cyclopentanecarboxamide; 4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile; With potassium iodide; potassium hydroxide; In acetonitrile; at 20 ℃; for 2h;

With hydrogenchloride; In water; acetonitrile; pH=4 - 5; Product distribution / selectivity;

upstream raw materials:

N-pentanoylaminocyclopentane-1-carboxylic acid

[(2'-cyanobiphenyl-4-yl)methyl]amine

1-cyano-1-n-pentanoylaminocyclopentane

n-valeryl chloride

Downstream raw materials:

4'-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-[1,1'-biphenyl]-2-carbonitrile

2-butyl-3-{4-[2-(1H-tetrazol-5-yl)phenyl]benzyl}-1,3-diazaspiro[4.4]non-1-en-4-one

2-n-butyl-4-spirocyclopentane-1-[((2'-tetrazol-5-yl)biphenyl-4-yl)methyl]-2-imidazolin-5-one hydrochloride