tert-Butyl 4-((4-bromophenyl)thio)piperidine-1-carboxylate

Base Information

Chemical Name:tert-Butyl 4-((4-bromophenyl)thio)piperidine-1-carboxylate
CAS No.:188527-03-9
Molecular Formula:C16H22BrNO2S
Molecular Weight:372.326
Hs Code.:2933399090
DSSTox Substance ID:DTXSID80471956
Wikidata:Q82300665
Mol file:188527-03-9.mol

Synonyms:tert-Butyl 4-((4-bromophenyl)thio)piperidine-1-carboxylate;188527-03-9;Tert-butyl 4-(4-bromophenyl)sulfanylpiperidine-1-carboxylate;N-BOC 4-(4-bromophenylthio)piperidine;SCHEMBL5440270;DTXSID80471956;tert-Butyl4-((4-bromophenyl)thio)piperidine-1-carboxylate;ZZOAAIWOHGSKMZ-UHFFFAOYSA-N;N-BOC 4-(4bromophenylthio)piperidine;CS-0336677;4-(4-bromothiophenoxy)-1-t-butoxycarbonylpiperidine;A1-18853;tert-butyl 4-(4-bromophenylthio)piperidine-1-carboxylate;tert-butyl 4-[(4-bromophenyl)sulfanyl]piperidine-1-carboxylate;4-(4-Bromo-phenylsulfanyl)-piperidine-1-carboxylic acid tert-butyl ester;1-Piperidinecarboxylic acid, 4-[(4-bromophenyl)thio]-, 1,1-dimethylethyl ester

Suppliers and Price of tert-Butyl 4-((4-bromophenyl)thio)piperidine-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
tert-Butyl4-((4-bromophenyl)thio)piperidine-1-carboxylate 95+%
1g
$ 614.00

Chemenu
tert-butyl4-((4-bromophenyl)thio)piperidine-1-carboxylate 95%
1g
$ 580.00

American Custom Chemicals Corporation
TERT-BUTYL 4-((4-BROMOPHENYL)THIO)PIPERIDINE-1-CARBOXYLATE 95.00%
5MG
$ 503.17

A1 Biochem Labs
tert-Butyl4-(4-bromophenyl)sulfanylpiperidine-1-carboxylate 95%
2.5 g
$ 950.00

Total 8 raw suppliers

Chemical Property of tert-Butyl 4-((4-bromophenyl)thio)piperidine-1-carboxylate

Chemical Property:

PSA：54.84000
LogP:4.87860
XLogP3:4.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:371.05546
Heavy Atom Count:21
Complexity:343

Purity/Quality:

99% ^*data from raw suppliers

tert-Butyl4-((4-bromophenyl)thio)piperidine-1-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)(C)OC(=O)N1CCC(CC1)SC2=CC=C(C=C2)Br

Technology Process of tert-Butyl 4-((4-bromophenyl)thio)piperidine-1-carboxylate

There total 6 articles about tert-Butyl 4-((4-bromophenyl)thio)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 106-53-6
para-bromobenzenethiol

: 141699-59-4
1-(tert-butoxycarbonyl)piperidin-4-yl methanesulfonate

: 188527-03-9
4-(4-bromophenylsulfanyl)piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With potassium carbonate; In acetonitrile; for 18h; Heating;
DOI:10.1021/jm011030v

Reference yield: 41.0%

: 106-53-6
para-bromobenzenethiol

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

: 188527-03-9
4-(4-bromophenylsulfanyl)piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 25 ℃; for 16h;
DOI:10.1016/j.bmcl.2014.12.026

Reference yield:

: 5382-16-1
4-HYDROXYPIPERIDINE

: 188527-03-9
4-(4-bromophenylsulfanyl)piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 0 - 20 °C

2: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

With triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; 2: |Mitsunobu Displacement;